Motesin (Azelastine Hydrochloride, Fluticasone Propionate)

Azelastine Hydrochloride and Fluticasone Propionate, the active ingredients in Motesin, are an antihistamine and a corticosteroid presented as a nasal spray for nasal administration. They are used to relieve symptoms of allergic rhinitis, including seasonal and perennial forms, in patients as directed by a healthcare professional. The product is approved in the European Union and is available by prescription only.

GNH USA supplies Motesin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide and complies with international quality standards.

Motesin combines an antihistamine and a corticosteroid to treat nasal allergy pathways.

Allergic rhinitis: alleviates nasal congestion, sneezing, itching and watery discharge, improving overall nasal comfort. Seasonal allergic rhinitis: mitigates symptoms caused by pollen or other seasonal allergens, reducing the impact on daily activities. Perennial allergic rhinitis: controls year‑round nasal allergy symptoms, helping maintain normal breathing and sleep quality. Nasal symptoms associated with allergic rhinitis: reduces inflammation and histamine response in the nasal mucosa, providing broader symptom relief.

Motesin may cause local and systemic adverse reactions, most of which are mild and transient.

Common Side Effects: - Nasal irritation or burning sensation - Bitter or unpleasant taste - Headache - Mild nosebleeds (epistaxis) - Throat irritation or dryness - Cough

Serious or Rare Side Effects: - Severe or prolonged nosebleeds - Allergic reactions including anaphylaxis - Adrenal suppression with prolonged use - Vision changes such as cataracts or glaucoma - Fungal infection of the nasal passages - Growth suppression in children (rare)

Before using Motesin, consider the following safety measures.

Hypersensitivity: avoid use in patients with known allergy to azelastine, fluticasone or excipients. Nasal surgery or trauma: postpone use until healing is complete. Pregnancy and lactation: consult a healthcare provider before use. Pediatric use: use only under medical supervision, monitor growth. Concomitant immunosuppressants: assess risk of local infection. Store at room temperature: keep below 25°C, protect from moisture and direct sunlight.

Motesin can interact with other medicines; review the following categories.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors: may increase systemic exposure to fluticasone. - Live vaccines: systemic corticosteroid effect may reduce vaccine efficacy.

Moderate Interactions (Monitor Closely): - Antihistamines: monitor for increased nasal dryness or irritation. - Oral corticosteroids: cumulative glucocorticoid effect may raise risk of systemic side effects. - Nasal decongestants: may increase local irritation when used together.