Morsadex (Dexketoprofen)

Dexketoprofen, the active ingredient in Morsadex, is a NSAID presented as a injectable solution for intramuscular and intravenous use. It treats acute pain and inflammatory conditions in adult patients who require rapid analgesia.

GNH USA supplies Morsadex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Dexketoprofen is an NSAID that reduces pain and inflammation through cyclo‑oxygenase inhibition. It is indicated for several acute pain settings: - Postoperative pain: provides rapid analgesia after surgical procedures. - Musculoskeletal pain: relieves pain associated with strains, sprains, and soft‑tissue injuries. - Inflammatory conditions: reduces discomfort in acute inflammatory episodes such as tendonitis or bursitis.

Adverse reactions may occur with any NSAID injection. They are categorised by frequency and severity.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Headache: transient cranial discomfort. - Dizziness: occasional light‑headedness. - Injection‑site pain: local discomfort at the administration site. - Dyspepsia: indigestion or heartburn. - Diarrhoea: loose stools.

Serious or Rare Side Effects: - Gastrointestinal bleeding: potentially life‑threatening haemorrhage. - Renal impairment: reduced kidney function or acute failure. - Severe allergic reactions: anaphylaxis, angioedema, or urticaria. - Stevens‑Johnson syndrome: rare severe skin reaction. - Hepatotoxicity: liver enzyme elevations or hepatitis. - Cardiovascular events: increased risk of thrombotic events in susceptible patients.

Before prescribing Dexketoprofen, clinicians should evaluate patient‑specific risk factors and monitor for adverse events. - Renal function: assess baseline kidney status and avoid in severe impairment. - Gastrointestinal risk: avoid in patients with active peptic ulcer disease or recent GI bleeding. - Cardiovascular disease: use cautiously in patients with coronary artery disease or hypertension. - Bleeding tendency: monitor closely if the patient is on anticoagulants or antiplatelet agents. - Pregnancy and lactation: avoid unless the benefit clearly outweighs the risk. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Dexketoprofen may interact with several drug classes, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): heightened risk of serious bleeding. - Other NSAIDs or aspirin: additive gastrointestinal and renal toxicity. - Corticosteroids: increased risk of GI ulceration and bleeding.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may impair renal function, especially in volume‑depleted patients. - Diuretics: potential for reduced renal perfusion and electrolyte disturbances. - Lithium: NSAIDs can raise lithium levels, risking toxicity. - Methotrexate: reduced clearance may lead to toxicity.