GNH USA

Europe — EMA

Monurol (Fosfomycin)

GNH USA supplies Monurol (Fosfomycin), a phosphonic acid antibiotic for uncomplicated urinary tract infections. Request a quote for global supply worldwide.

Fosfomycin

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What is Fosfomycin?

Fosfomycin, the active ingredient in Monurol, is a phosphonic acid antibiotic presented as an oral tablet for systemic use. It is indicated for the treatment of uncomplicated urinary tract infections caused by susceptible bacteria in adult patients.

GNH USA supplies Monurol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for global healthcare providers. Our distribution network ensures timely delivery and regulatory compliance across multiple regions.

What is Fosfomycin used for?

Monurol (fosfomycin) is used to treat infections of the urinary tract caused by susceptible bacteria.

Uncomplicated urinary tract infection: single‑dose oral therapy that eradicates susceptible bacteria. Acute uncomplicated cystitis: rapid symptom relief and bacterial clearance with a one‑time dose. Lower urinary tract infection caused by susceptible strains: effective oral treatment option.

What are the side effects of Fosfomycin?

Fosfomycin may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Nausea - Diarrhea - Abdominal discomfort - Headache - Dizziness - Flatulence

Serious or Rare Side Effects: - Allergic reactions such as rash, itching, or anaphylaxis - Clostridioides difficile‑associated colitis - Elevated liver enzymes or hepatic dysfunction - Severe skin reactions including Stevens‑Johnson syndrome or toxic epidermal necrolysis - Renal impairment - Hematologic abnormalities

What precautions apply to Fosfomycin?

Before prescribing Monurol, clinicians should consider several safety precautions to minimize risk. - Renal function assessment: adjust use in patients with severe renal impairment - Known hypersensitivity: avoid in individuals with previous fosfomycin allergy - Pregnancy status: evaluate benefits versus risks as safety data are limited - Concomitant medications: review for potential drug interactions that may affect efficacy - Gastrointestinal tolerance: monitor for persistent nausea or diarrhea - Store at ambient temperature: keep in original packaging, protect from moisture

What does Fosfomycin interact with?

Fosfomycin can interact with other medicines, affecting its absorption or therapeutic effect.

Major Interactions (Avoid): - Antacids containing magnesium or aluminum: significantly reduce fosfomycin absorption - Metoclopramide or other pro‑kinetic agents: delay gastric emptying and lower bioavailability - Concurrent use with other bactericidal antibiotics that may antagonize its action

Moderate Interactions (Monitor Closely): - Warfarin: possible increase in INR, monitor coagulation parameters - Oral contraceptives: reduced effectiveness, advise additional contraceptive measures - Diabetic agents: fosfomycin may alter glucose control, monitor blood sugar levels

Frequently asked questions

What is Monurol used for?+
Monurol contains fosfomycin and is indicated for the treatment of uncomplicated urinary tract infections caused by susceptible bacteria. It is commonly prescribed for adult patients presenting with acute cystitis or other lower urinary tract infections where the pathogen is known to be sensitive to fosfomycin.
How does fosfomycin work?+
Fosfomycin inhibits bacterial cell‑wall synthesis by blocking the MurA enzyme, which is essential for the formation of N‑acetylmuramic acid, a key building block of peptidoglycan. This interruption weakens the bacterial wall, leading to cell lysis and death, particularly against many Gram‑negative uropathogens.
What is the usual dose of Monurol?+
The dosage of Monurol is determined by the prescribing clinician based on the patient’s condition, renal function, and local guidelines. In most cases a single oral dose is administered, but the exact amount and any repeat dosing must be specified by a qualified healthcare professional.
Is Monurol safe during pregnancy or breastfeeding?+
Safety data for fosfomycin in pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against possible risks and consider alternative therapies when appropriate. Women who are pregnant or breastfeeding should discuss use of Monurol with their physician before starting treatment.
How do I order Monurol from GNH USA?+
To request Monurol, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams across international markets, and will ask you to confirm trade or institutional credentials. The team then replies with pricing, availability, shipping details and any necessary import documentation.
How does Monurol compare with the main alternative drug or class?+
Compared with nitrofurantoin or trimethoprim‑sulfamethoxazole, fosfomycin offers a single‑dose regimen and retains activity against many multidrug‑resistant uropathogens. However, its spectrum is narrower, and resistance can develop if used repeatedly. Choice of therapy should be guided by local susceptibility patterns and patient‑specific factors.
What are the storage and handling requirements for Monurol?+
Monurol tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or container to protect them from moisture and light. Keep the product out of reach of children and avoid storing in areas with high humidity or extreme heat.
How is Monurol administered?+
Monurol is taken orally, usually as a single tablet with a full glass of water. It is often recommended to take the dose on an empty stomach, at least 30 minutes before or 2 hours after a meal, to maximize absorption. Follow the prescribing clinician’s instructions for timing.
What are the most serious risks to watch for while taking Monurol?+
The most serious adverse reactions include severe allergic responses such as rash, itching, swelling, or anaphylaxis, and Clostridioides difficile‑associated colitis presenting as persistent watery diarrhea. Signs of liver dysfunction (jaundice, dark urine) or severe skin reactions (Stevens‑Johnson syndrome) also require immediate medical attention.
Who should not use Monurol?+
Monurol should be avoided in individuals with a known hypersensitivity to fosfomycin or any component of the formulation. Patients with severe renal impairment may require dose adjustment or alternative therapy. It is also contraindicated in those who have experienced serious allergic reactions to other antibiotics in the same class.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Fosfomycin
Route
Oral Use
Manufacturer
Zambon, S.A.U.
Origin
EU

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