GNH USA

Europe — EMA

Monuril (Fosfomycin Trometamol)

GNH USA supplies Monuril (Fosfomycin Trometamol), a phosphonic acid antibiotic for uncomplicated urinary tract infections. Request a quote for global supply.

Fosfomycin Trometamol

Request sourcing

1
Pack/s

What is Fosfomycin Trometamol?

Fosfomycin Trometamol, the active ingredient in Monuril, is a phosphonic acid antibiotic presented as an oral tablet for oral use. It treats uncomplicated urinary tract infection in adult women and men who require a single‑dose regimen. GNH USA supplies Monuril as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Fosfomycin Trometamol used for?

Monuril is a phosphonic acid antibiotic used to treat infections of the lower urinary tract. - Uncomplicated urinary tract infection: provides a single oral dose that eradicates susceptible uropathogens. - Acute cystitis: relieves symptoms and clears bacterial growth in the bladder. - Recurrent UTI prophylaxis: may be used intermittently to reduce the frequency of future uncomplicated infections.

What are the side effects of Fosfomycin Trometamol?

Common side effects are generally mild and transient.

Common Side Effects: - Nausea: mild stomach upset after the dose. - Diarrhea: loose stools occurring within 24‑48 hours. - Headache: mild to moderate headache. - Abdominal pain: cramping or discomfort in the abdomen. - Dyspepsia: indigestion or heartburn. - Flatulence: increased gas production.

Serious or Rare Side Effects: - Allergic reaction: rash, itching, or swelling. - Severe skin rash: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Clostridioides difficile infection: severe colitis. - Liver enzyme elevation: abnormal hepatic function tests. - Anaphylaxis: life‑threatening hypersensitivity. - Renal impairment: worsening kidney function in susceptible patients.

What precautions apply to Fosfomycin Trometamol?

Before prescribing Monuril, clinicians should consider patient‑specific factors. - Assess renal function: dose adjustment may be required in severe impairment. - Review allergy history: avoid in patients with known fosfomycin hypersensitivity. - Pregnancy considerations: use only if benefits outweigh potential risks. - Monitor gastrointestinal tolerance: advise patients to report persistent diarrhea. - Store at below 25°C: keep in the original pack, protect from moisture.

What does Fosfomycin Trometamol interact with?

Fosfomycin can interact with several medicines that affect absorption or renal handling.

Major Interactions (Avoid): - Antacids containing magnesium or aluminum: markedly reduce fosfomycin absorption. - Metformin: may increase risk of lactic acidosis in renal impairment. - Warfarin: potential alteration of INR, requiring close monitoring.

Moderate Interactions (Monitor Closely): - Oral contraceptives: possible reduction in contraceptive efficacy. - Other antibiotics (e.g., aminoglycosides): potential antagonistic effect. - Diuretics: may modify renal excretion of fosfomycin.

Frequently asked questions

What is Monuril used for?+
Monuril contains fosfomycin trometamol and is indicated for the treatment of uncomplicated urinary tract infections caused by susceptible bacteria. It is administered as a single oral dose, providing convenient therapy for acute cystitis in adult patients.
How does fosfomycin trometamol work?+
Fosfomycin trometamol blocks the enzyme MurA, which is essential for the synthesis of N‑acetylmuramic acid, a building block of bacterial cell walls. By preventing cell‑wall formation, the drug leads to bacterial lysis and eradication of the infecting organisms.
What is the usual dose of Monuril?+
The prescribed dose of Monuril is determined by the treating clinician based on the patient’s condition, renal function, and local guidelines. The medication is supplied as a single‑dose oral tablet, and the exact amount should be confirmed by the prescriber.
Is Monuril safe during pregnancy or breastfeeding?+
Safety data for fosfomycin trometamol in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.
How do I order Monuril from GNH USA?+
To request Monuril, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Monuril compare with other UTI antibiotics?+
Monuril offers a single‑dose oral regimen, which differs from multi‑day courses of trimethoprim‑sulfamethoxazole or nitrofurantoin. Its unique mechanism targeting cell‑wall synthesis can be effective against resistant strains, but susceptibility testing is recommended to ensure optimal therapy.
What are the storage requirements for Monuril?+
Monuril tablets should be stored at temperatures below 25 °C, in the original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool environment maintains its stability and potency.
How is Monuril administered?+
Monuril is taken orally as a single tablet with a full glass of water, preferably on an empty stomach. Patients should avoid food, antacids, or dairy products for at least two hours before and after dosing to ensure optimal absorption.
What are the most serious risks associated with Monuril?+
Serious adverse events, though rare, include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, and Clostridioides difficile‑associated colitis. Patients should seek immediate medical attention if they develop rash, fever, persistent diarrhea, or signs of an allergic response.
Who should not use Monuril?+
Monuril is contraindicated in individuals with a known hypersensitivity to fosfomycin or any of its excipients. Caution is also advised for patients with severe renal impairment, pregnant or breastfeeding women unless clearly indicated, and those taking medications that may cause major interactions.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Fosfomycin Trometamol
Route
Oral Use
Manufacturer
Zambon - Produtos Farmacêuticos, Lda.
Origin
EU

Related products

Afastural

Afastural

Fosfomycin Trometamol

Exeltis Poland Sp. Z O.O.
EU
Afosfol

Afosfol

Fosfomycin Trometamol

Axunio Pharma Gmbh
EU
Alexi

Alexi

Fosfomycin Trometamol

Rudipharm Limited
EU
Berny Adulti

Berny Adulti

Fosfomycin Trometamol

So.Se.Pharm S.R.L.
EU