Monuril (Fosfomycin Trometamol)

Fosfomycin Trometamol, the active ingredient in Monuril, is a phosphonic acid antibiotic presented as an oral powder for solution for oral use. It treats uncomplicated urinary tract infection, primarily in adult women, by delivering a single‑dose antibacterial effect.

GNH USA supplies Monuril as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Monuril is a phosphonic acid antibiotic used to manage infections of the urinary tract caused by susceptible bacteria. - Uncomplicated cystitis (female): single dose eradicates the causative bacteria and relieves symptoms. - Uncomplicated cystitis (male): provides bacterial clearance with a convenient one‑time regimen. - Uncomplicated urinary tract infection (adults): resolves symptoms and helps prevent early recurrence.

Adverse reactions may occur with any medication. Common side effects are usually mild and transient.

Common Side Effects: - Nausea - Diarrhoea - Headache - Abdominal pain - Flatulence - Dyspepsia

Serious or Rare Side Effects: - Allergic reactions (rash, pruritus, angio‑edema) - Anaphylaxis - Severe skin reactions such as Stevens‑Johnson syndrome - Clostridioides difficile‑associated colitis - Hepatic dysfunction (elevated transaminases) - Hematologic abnormalities (eosinophilia, neutropenia)

Before prescribing Monuril, clinicians should consider patient‑specific factors and safety measures. - Assess renal function: adjust use in severe renal impairment. - Avoid use in patients with known hypersensitivity to fosfomycin or its excipients. - Use with caution in pregnancy: safety not established; weigh benefits against potential risks. - Monitor for gastrointestinal disturbances, especially in patients with a history of diarrhoea. - Review concomitant medications for possible interactions. - Store at ambient temperature: keep in the original pack, protect from moisture.

Fosfomycin may interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid): - Co‑administration with antacids containing magnesium or aluminum: markedly reduces fosfomycin absorption. - Concurrent use with metoclopramide: may decrease fosfomycin bioavailability.

Moderate Interactions (Monitor Closely): - Combination with oral contraceptives: may reduce contraceptive effectiveness; advise additional barrier methods. - Use with warfarin: monitor INR closely for potential anticoagulant effect alteration. - Concomitant use with other antibiotics: assess for additive gastrointestinal side effects.