Monuril (Fosfomycin Trometamol)

Fosfomycin trometamol, the active ingredient in Monuril, is a phosphonic acid antibiotic presented as an oral tablet for oral use. It treats uncomplicated urinary tract infections in adult patients. GNH USA supplies Monuril as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Monuril (fosfomycin trometamol) is indicated for infections of the urinary tract caused by susceptible bacteria.

- Uncomplicated urinary tract infection: provides a single‑dose bactericidal treatment of susceptible uropathogens.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Diarrhea: loose stools, usually self‑limiting. - Headache: transient cranial discomfort. - Abdominal pain: cramping or discomfort in the abdomen. - Vomiting: occasional emesis. - Dyspepsia: indigestion or heartburn.

Serious or Rare Side Effects: - Allergic reactions: rash, pruritus, or anaphylaxis. - Clostridioides difficile infection: severe colitis. - Hepatic injury: elevated liver enzymes or jaundice. - Hematologic effects: thrombocytopenia or leukopenia. - Renal impairment: worsening kidney function. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Before prescribing Monuril, consider the following safety measures.

- Renal function: assess kidney function; adjust use in severe impairment. - Pregnancy: safety not established; avoid unless benefit outweighs risk. - Breastfeeding: unknown excretion; weigh potential infant exposure. - Drug interactions: avoid concomitant antacids or supplements containing divalent cations. - Pediatric use: not recommended as safety and efficacy are not established. - Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Monuril may interact with other medicines, influencing its absorption or effect.

Major Interactions (Avoid): - Antacids with magnesium or aluminum: markedly reduce fosfomycin absorption. - Calcium‑containing antacids or supplements: decrease bioavailability. - Iron supplements: impair oral uptake of the drug. - Sucralfate: forms complexes that limit absorption.

Moderate Interactions (Monitor Closely): - Warfarin: monitor INR for potential anticoagulant effect changes. - Metformin: observe renal function to reduce lactic acidosis risk. - Diuretics: watch electrolytes and renal status. - NSAIDs: assess renal function when used together.