Monuril (Fosfomycin Trometamol)

Fosfomycin trometamol, the active ingredient in Monuril, is a fosfomycin presented as a 3 g oral powder for solution for oral use. It treats acute uncomplicated urinary tract infection (cystitis) in adult women. GNH USA supplies Monuril as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Fosfomycin trometamol is an antibacterial agent used primarily for urinary tract infections.

Acute uncomplicated urinary tract infection (cystitis): provides a single‑dose eradication of susceptible uropathogens. Recurrent urinary tract infection prophylaxis: reduces recurrence when administered intermittently. Infections caused by susceptible Enterobacteriaceae: effective against uncomplicated lower urinary tract infections when the pathogen is known to be sensitive.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Diarrhoea: watery stools, usually transient. - Abdominal pain or discomfort. - Headache: dull or throbbing. - Taste disturbance: metallic or altered taste perception. - Flatulence: increased gas production.

Serious or Rare Side Effects: - Allergic reactions: rash, urticaria, or anaphylaxis. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Clostridioides difficile infection: colitis presenting with severe diarrhoea. - Hepatic dysfunction: elevated liver enzymes or jaundice. - Renal impairment: worsening kidney function in susceptible patients. - Severe hypersensitivity: eosinophilia or systemic inflammatory response.

Before prescribing Monuril, consider the following precautions: - Renal function assessment: adjust use in patients with severe renal impairment. - Pregnancy safety: category unknown; avoid unless benefits outweigh risks. - Hepatic impairment: use with caution in patients with liver disease. - Known hypersensitivity: do not use in individuals with documented allergy to fosfomycin or its excipients. - Concomitant antacids: may reduce absorption; separate administration by at least 2 hours. - Store below 25°C: keep in the original pack, protect from moisture.

Fosfomycin trometamol can interact with several medicines.

Major Interactions (Avoid): - Probenecid: reduces renal excretion, increasing systemic exposure. - Cimetidine: decreases intestinal absorption, lowering efficacy. - Antacids containing magnesium or aluminium: markedly reduce fosfomycin absorption.

Moderate Interactions (Monitor Closely): - Warfarin: possible alteration of INR; monitor coagulation parameters. - Oral contraceptives: may reduce hormonal effectiveness; advise additional contraception. - Diuretics: altered renal clearance may affect drug levels; observe renal function.