Monural (Fosfomycin Trometamol)

Fosfomycin Trometamol, the active ingredient in Monural, is a phosphonic acid antibiotic presented as an oral powder for solution for oral use. It is indicated for the treatment of uncomplicated urinary tract infections in adult patients. GNH USA supplies Monural as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Monural is a phosphonic acid antibiotic used to treat infections of the urinary tract caused by susceptible bacteria.

Uncomplicated urinary tract infection: provides a single‑dose oral therapy that clears acute cystitis caused by common uropathogens. Acute uncomplicated cystitis: achieves rapid symptom relief and bacterial eradication in women with first‑time infections.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Diarrhea: loose stools occurring within 24‑48 hours. - Headache: transient tension‑type headache. - Abdominal discomfort: cramping or mild pain. - Vomiting: occasional emesis. - Dizziness: brief episodes of light‑headedness.

Serious or Rare Side Effects: - Allergic reactions: rash, itching, or anaphylaxis. - Clostridioides difficile infection: severe colitis risk. - Hepatic dysfunction: elevated liver enzymes. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Hemolytic anemia: reduced red blood cell count.

Before prescribing Monural, consider the following precautions: - Renal impairment: assess kidney function and adjust use if necessary. - Pregnancy and lactation: safety not established; use only if benefits outweigh risks. - Known allergy to fosfomycin: avoid administration. - Concomitant medications: review for potential interactions. - Storage: Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Monural may interact with several medicines.

Major Interactions (Avoid): - Probenecid: reduces urinary excretion of fosfomycin, lowering efficacy. - Ceftriaxone: potential antagonistic effect when used together.

Moderate Interactions (Monitor Closely): - Antacids containing magnesium or aluminum: may decrease fosfomycin absorption. - Metformin: monitor renal function as both are renally cleared. - Warfarin: may increase INR; monitor coagulation parameters.