Monural (Fosfomycin Trometamol)

Fosfomycin trometamol, the active ingredient in Monural, is an antibiotic presented as an oral dosage form for systemic use. It is employed to treat acute uncomplicated urinary tract infections, particularly cystitis, in adult patients. The drug achieves bacterial eradication with a single dose, targeting common uropathogens such as Escherichia coli.

GNH USA supplies Monural as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our global distribution network ensures reliable access to quality‑assured medicines across regulated markets, adhering to stringent manufacturing and supply standards.

Monural is used to treat infections of the urinary tract by targeting the bacterial cause of cystitis.

Acute uncomplicated urinary tract infection (cystitis): provides rapid bacterial eradication with a single oral dose, relieving symptoms and preventing recurrence.

Oral fosfomycin may be associated with a range of adverse reactions, most of which are mild and self‑limiting.

Common Side Effects: - Nausea: mild stomach upset after ingestion. - Diarrhea: loose stools that usually resolve without treatment. - Headache: transient mild headache. - Abdominal discomfort: cramping or mild pain.

Serious or Rare Side Effects: - Anaphylaxis: severe allergic reaction requiring immediate medical attention. - Stevens‑Johnson syndrome: rare but serious skin eruption. - Clostridioides difficile colitis: severe intestinal infection that may occur after antibiotic use.

Before prescribing Monural, clinicians should consider several precautionary measures to ensure safe use. - Renal function assessment: adjust use in patients with severe renal impairment. - Pregnancy and lactation: evaluate risk‑benefit, as safety data are limited. - Concomitant antibiotics: avoid use with agents that may antagonize fosfomycin activity. - History of hypersensitivity: contraindicated in patients with known allergy to fosfomycin or related compounds. - Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Fosfomycin can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Antacids containing divalent cations (e.g., calcium, magnesium, aluminium): significantly reduce fosfomycin absorption. - Probenecid: may increase fosfomycin plasma concentrations, raising risk of toxicity.

Moderate Interactions (Monitor Closely): - Warfarin: occasional reports of altered INR; monitor coagulation parameters. - Oral contraceptives: potential reduction in contraceptive effectiveness; advise additional non‑hormonal contraception.