Montelukast Ratiopharm (Montelukast Sodium)

Montelukast, the active ingredient in Montelukast Ratiopharm, is a leukotriene receptor antagonist presented as a tablet for oral use. It is employed to manage asthma and allergic rhinitis by reducing inflammation and bronchoconstriction in patients of all ages.

GNH USA supplies Montelukast Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier, ensuring quality and regulatory compliance while serving hospitals, pharmacies and clinics worldwide. Our global distribution network facilitates reliable delivery across Europe, Asia, Africa and the Americas. We adhere to stringent quality assurance protocols to meet the expectations of healthcare professionals.

Montelukast acts on the leukotriene pathway to control respiratory and allergic conditions.

- Asthma: improves symptom control and reduces the frequency of exacerbations. - Allergic rhinitis: alleviates nasal congestion, sneezing, itching and rhinorrhoea. - Exercise‑induced bronchoconstriction: helps prevent airway narrowing during physical activity.

Montelukast is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Headache: mild to moderate pain often reported. - Abdominal pain: discomfort in the stomach region. - Cough: transient irritation of the airway. - Nausea: feeling of queasiness. - Diarrhoea: loose stools. - Fatigue: unusual tiredness.

Serious or Rare Side Effects: - Allergic reactions: rash, urticaria, angioedema, or anaphylaxis. - Mood changes: depression, suicidal thoughts or behaviour. - Hepatic enzyme elevation: abnormal liver function tests. - Neutropenia: reduced white‑blood‑cell count. - Stevens‑Johnson syndrome: severe skin and mucous membrane disorder.

Before prescribing Montelukast, clinicians should consider several safety aspects.

- Assess liver function: monitor hepatic enzymes in patients with known liver disease. - Avoid use in patients with known hypersensitivity: discontinue if allergic reaction occurs. - Use caution in patients with psychiatric disorders: monitor for mood changes or suicidal ideation. - Consider dose adjustment in severe renal impairment: evaluate renal function before initiation. - Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Montelukast may interact with other medicines, requiring attention to the level of interaction.

Major Interactions (Avoid): - Ritonavir: can increase montelukast plasma concentrations. - Phenobarbital: may reduce montelukast effectiveness. - Ketoconazole: may elevate montelukast levels.

Moderate Interactions (Monitor Closely): - Warfarin: possible alteration of INR, requiring coagulation monitoring. - Theophylline: additive bronchial effects may require dose review. - Fluconazole: may modestly increase montelukast exposure.