Montelukast Cristers

Montelukast, the active ingredient in Montelukast Cristers, is a leukotriene receptor antagonist presented as an oral tablet for oral use. It is used to manage asthma, allergic rhinitis and exercise‑induced bronchoconstriction in adults and children as directed by a healthcare professional.

GNH USA supplies Montelukast Cristers as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Montelukast acts on leukotriene pathways to control airway inflammation and bronchoconstriction. - Asthma: improves symptom control and reduces exacerbations. - Allergic rhinitis: relieves nasal congestion, sneezing and itching. - Exercise‑induced bronchoconstriction: prevents airway narrowing triggered by physical activity.

Montelukast is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Headache: mild to moderate pain often resolves without intervention. - Upper respiratory tract infection: symptoms such as sore throat or nasal congestion. - Abdominal pain: intermittent discomfort or cramping. - Cough: occasional dry or productive cough. - Diarrhoea: loose stools that are usually self‑limiting. - Rash: mild skin irritation or erythema.

Serious or Rare Side Effects: - Mood changes: depression, anxiety, or suicidal thoughts. - Allergic reactions: hives, swelling, or anaphylaxis. - Liver enzyme elevation: abnormal hepatic function tests. - Stevens‑Johnson syndrome: severe skin blistering and mucosal involvement. - Angio‑edema: rapid swelling of face, lips or tongue. - Blood dyscrasias: rare cases of neutropenia or thrombocytopenia.

Montelukast should be used with awareness of specific safety considerations. - Pregnancy: Category B – generally considered safe, but use only if clearly needed. - Breastfeeding: excreted in milk; benefits and risks should be evaluated. - Hepatic impairment: monitor liver function in patients with existing liver disease. - Psychiatric symptoms: observe for mood changes, especially in adolescents. - Drug interactions: review concomitant medications for potential interactions. - Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Montelukast may interact with other medicines that affect the same metabolic pathways or exacerbate side effects.

Major Interactions (Avoid): - Phenobarbital: induces hepatic enzymes, reducing montelukast exposure. - Rifampin: strong enzyme inducer that may lower therapeutic levels.

Moderate Interactions (Monitor Closely): - Antidepressants (SSRIs, SNRIs): may increase risk of neuropsychiatric events. - Warfarin: occasional reports of altered INR; monitor coagulation parameters. - Other leukotriene modifiers: additive effects on leukotriene pathways; assess clinical need. - CYP2C9 substrates: potential modest changes in plasma concentrations. - Herbal supplements (St. John’s wort): enzyme induction may reduce efficacy.