Montelukast Aurobindo

Montelukast, the active ingredient in Montelukast Aurobindo, is a leukotriene receptor antagonist presented as an oral dosage form for oral use. It is used to treat asthma, allergic rhinitis and exercise‑induced bronchoconstriction in both adults and children. GNH USA supplies Montelukast Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Montelukast is a leukotriene receptor antagonist used in respiratory and allergic disorders.

- Asthma: provides maintenance therapy that reduces the frequency and severity of symptoms. - Allergic rhinitis: relieves nasal congestion, sneezing and itchy eyes associated with seasonal allergies. - Exercise‑induced bronchoconstriction: prevents airway narrowing that occurs during physical activity.

Montelukast may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Headache: mild to moderate intensity. - Abdominal pain: occasional discomfort. - Cough: transient irritation. - Sore throat: mild irritation of the pharynx. - Nausea: occasional upset stomach. - Diarrhoea: loose stools.

Serious or Rare Side Effects: - Allergic reactions: rash, angioedema, or anaphylaxis. - Neuropsychiatric events: mood changes, depression, or suicidal thoughts. - Hepatic enzyme elevation: abnormal liver function tests. - Neutropenia: reduced white blood cell count. - Severe skin reactions: Stevens‑Johnson syndrome. - Anaphylaxis: rare but life‑threatening hypersensitivity.

Before prescribing Montelukast, clinicians should consider several safety aspects.

- Assess asthma control: ensure baseline control before adding therapy. - Monitor neuropsychiatric symptoms: watch for mood changes or depression. - Use caution in hepatic impairment: dose adjustment may be required. - Avoid in known hypersensitivity: discontinue if allergic reaction occurs. - Pregnancy and breastfeeding: discuss risks and benefits with the prescriber. - Store below 25°C: keep in the original pack, protect from moisture.

Montelukast can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid): - Ritonavir: may increase montelukast plasma concentrations. - Phenobarbital: may lower montelukast effectiveness. - Carbamazepine: may reduce montelukast levels.

Moderate Interactions (Monitor Closely): - Warfarin: possible effect on INR, monitor coagulation. - Theophylline: additive bronchodilator effect, observe respiratory response. - Fluconazole: may raise montelukast concentrations, adjust if needed.