Montelucaste Tetrafarma (Montelukast)

Montelukast, the active ingredient in Montelucaste Tetrafarma, is a leukotriene receptor antagonist presented as an oral dosage form for oral use. It is used to manage asthma, exercise‑induced bronchoconstriction and allergic rhinitis in patients requiring control of leukotriene‑mediated airway inflammation.

GNH USA supplies Montelucaste Tetrafarma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Montelukast acts on the leukotriene pathway to reduce airway inflammation and bronchoconstriction. - Asthma: improves long‑term control and reduces the frequency of asthma attacks in adults and children. - Exercise‑induced bronchoconstriction: prevents narrowing of the airways that occurs during or after physical activity. - Allergic rhinitis: alleviates nasal congestion, sneezing and itching caused by seasonal or perennial allergens.

Montelukast is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Headache: mild to moderate pain often reported during early treatment. - Abdominal pain: discomfort or cramps in the stomach region. - Nausea: feeling of queasiness without vomiting. - Dizziness: transient sense of light‑headedness.

Serious or Rare Side Effects: - Allergic reactions: rash, itching, swelling, or difficulty breathing. - Neuropsychiatric events: mood changes, agitation, or suicidal thoughts. - Hepatic injury: abnormal liver function tests or jaundice. - Angioedema: rapid swelling of the face, lips, or tongue. - Stevens‑Johnson syndrome: severe skin blistering and mucosal involvement.

Before prescribing Montelukast, clinicians should consider several safety aspects. - Assess asthma control: ensure baseline control before adding therapy. - Monitor neuropsychiatric symptoms: watch for mood changes or suicidal ideation. - Use caution in hepatic impairment: adjust use if liver disease is present. - Avoid in known hypersensitivity: discontinue if allergic reaction occurs. - Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Montelukast may interact with other medicines, requiring attention to dosage and monitoring.

Major Interactions (Avoid): - Ritonavir: can increase montelukast plasma concentrations, raising risk of side effects. - Phenobarbital: may reduce montelukast effectiveness by enhancing metabolism.

Moderate Interactions (Monitor Closely): - Fluconazole: may modestly raise montelukast levels. - Carbamazepine: can lower montelukast exposure. - Warfarin: monitor INR as montelukast may affect anticoagulation control.