Monotrim (Trimethoprim)

Trimethoprim, the active ingredient in Monotrim, is an antibacterial presented as an oral tablet for systemic use. It is employed to treat bacterial infections of the urinary and respiratory tracts and is commonly prescribed for uncomplicated urinary tract infections in adults.

GNH USA supplies Monotrim as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across markets.

Trimethoprim is used to treat infections caused by susceptible bacteria in the urinary and respiratory systems.

- Urinary tract infection: eradicates causative bacteria and resolves dysuria, frequency and urgency. - Respiratory tract infection: treats acute bacterial bronchitis and sinusitis by eliminating the pathogen. - Travelers' diarrhea: provides antibacterial therapy for uncomplicated travel‑associated diarrhoea, reducing stool frequency and abdominal cramping.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Vomiting: occasional episodes after dosing. - Loss of appetite: reduced desire to eat. - Rash: mild skin irritation or erythema. - Headache: transient dull headache. - Elevated liver enzymes: mild, reversible increase.

Serious or Rare Side Effects: - Stevens‑Johnson syndrome: severe skin reaction requiring immediate discontinuation. - Agranulocytosis: marked drop in white blood cells, increasing infection risk. - Severe hepatic injury: jaundice or hepatitis. - Acute kidney injury: reduced renal function. - Hemolytic anemia in G6PD deficiency: rapid destruction of red blood cells.

Before initiating therapy, consider the following precautions: - Renal impairment: dose adjustment may be required. - Hepatic impairment: monitor liver function tests. - Pregnancy: safety category unknown; use only if benefits outweigh risks. - Breastfeeding: caution, as drug may be excreted in milk. - Allergic reactions: discontinue if hypersensitivity develops. - Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Trimethoprim may interact with several medicines.

Major Interactions (Avoid): - Methotrexate: increased toxicity due to overlapping folate inhibition. - Trimethoprim‑sulfamethoxazole combination: heightened risk of bone‑marrow suppression. - Warfarin: potentiates anticoagulant effect, increasing bleeding risk. - High‑dose folic acid supplements: may reduce antibacterial efficacy.

Moderate Interactions (Monitor Closely): - Loop diuretics: risk of hyperkalaemia. - ACE inhibitors: monitor serum potassium levels. - NSAIDs: may impair renal function, especially in dehydrated patients.