Monotab (Isosorbide Mononitrate)

Isosorbide mononitrate, the active ingredient in Monotab, is an organic nitrate presented as an oral tablet for oral use. It is used to prevent angina pectoris episodes and to treat chronic stable angina in adult patients.

GNH USA supplies Monotab as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Monotab belongs to the organic nitrate class and is used in the management of coronary artery disease.

Prophylaxis of angina pectoris: reduces the frequency of angina attacks during daily activities. Chronic stable angina: improves exercise tolerance and decreases symptom burden. Angina pectoris: provides symptomatic relief by enhancing myocardial oxygen supply.

Common Side Effects: - Headache: mild to moderate, often transient. - Dizziness or light‑headedness, especially on standing. - Flushing of the face or neck. - Nausea or upset stomach. - Palpitations or rapid heartbeat.

Serious or Rare Side Effects: - Severe hypotension leading to fainting. - Syncope or sudden loss of consciousness. - Allergic reactions such as rash, itching, or swelling. - Myocardial infarction in susceptible individuals. - Life‑threatening arrhythmias.

Before initiating therapy, consider the following precautions: - Cardiovascular assessment: evaluate blood pressure and heart rate. - Monitor for hypotension: especially when standing quickly. - Avoid abrupt discontinuation: taper to prevent rebound angina. - Use with caution in hepatic impairment: dose adjustment may be needed. - Use with caution in renal impairment: monitor renal function. - Store at below 25°C: keep in the original pack, protect from moisture.

Isosorbide mononitrate may interact with several drug classes.

Major Interactions (Avoid): - Other organic nitrates: additive vasodilatory effect causing severe hypotension. - Phosphodiesterase‑5 inhibitors (e.g., sildenafil): risk of profound blood pressure drop. - Strong antihypertensive agents: may produce excessive blood pressure reduction.

Moderate Interactions (Monitor Closely): - Diuretics: can enhance hypotensive response. - ACE inhibitors or ARBs: may require blood pressure monitoring. - Beta‑blockers: additive effect on heart rate and blood pressure. - Alcohol: can increase vasodilatory side effects. - Tobacco smoking: induces metabolism, potentially reducing efficacy.