Monosordil (Isosorbide 5 Mononitrate)

Isosorbide 5-mononitrate, the active ingredient in Monosordil, is a nitrate vasodilator presented as an oral tablet for oral use. It is employed to relieve episodes of angina pectoris by reducing myocardial oxygen demand in adult patients, providing prophylactic control of chest pain during physical exertion or stress.

GNH USA supplies Monosordil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality‑assured batches that meet EU regulatory standards and adhering to stringent manufacturing practices for reliable global distribution.

Monosordil (isosorbide 5‑mononitrate) belongs to the nitrate vasodilator class and is indicated for the management of angina pectoris, a condition characterized by chest discomfort due to myocardial ischemia.

- Angina pectoris: provides prophylactic relief of chest pain by decreasing myocardial oxygen consumption and improving coronary blood flow.

Monosordil may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects: - Headache: throbbing pain often occurring shortly after dosing. - Dizziness or light‑headedness: related to blood pressure reduction. - Flushing: warm sensation and reddening of the skin. - Hypotension: mild to moderate drop in blood pressure. - Nausea: occasional gastrointestinal upset.

Serious or Rare Side Effects: - Severe hypotension: marked blood pressure fall requiring medical attention. - Syncope: transient loss of consciousness. - Myocardial infarction: rare but possible in susceptible patients. - Allergic reaction: rash, itching, or swelling. - Tachycardia: rapid heart rate accompanying hypotension.

When prescribing Monosordil, clinicians should consider several safety measures. - Dose titration: start with a low dose and increase gradually to minimise hypotension. - Concomitant nitrates: avoid using with other nitrate preparations to prevent additive vasodilation. - Phosphodiesterase‑5 inhibitors: contraindicated due to risk of severe hypotension. - Blood pressure monitoring: regularly assess to detect excessive drops. - Pregnancy and lactation: safety unknown; use only if benefit outweighs potential risk. - Store at ambient temperature: keep below 25 °C in the original container, protected from moisture.

Monosordil can interact with several drug classes, requiring careful management.

Major Interactions (Avoid): - Phosphodiesterase‑5 inhibitors (e.g., sildenafil, tadalafil): risk of profound hypotension. - Other nitrates (e.g., isosorbide dinitrate, nitroglycerin): additive vasodilatory effect. - Sodium nitrite: may cause excessive vasodilation.

Moderate Interactions (Monitor Closely): - Antihypertensives (ACE inhibitors, beta‑blockers, calcium channel blockers): may enhance blood‑pressure‑lowering effect. - Alcohol: can increase hypotensive response. - Diuretics: may potentiate volume depletion and hypotension.