Monorem R (Isosorbide Mononitrate)

Isosorbide Mononitrate, the active ingredient in Monorem R, is a nitrate vasodilator presented as an oral tablet for oral use. It is indicated for the prophylaxis and treatment of angina pectoris in adults.

GNH USA supplies Monorem R as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand.

Isosorbide Mononitrate is used in the management of angina and related cardiovascular conditions.

- Stable angina: reduces frequency of chest pain episodes. - Chronic angina: improves exercise tolerance and reduces need for nitroglycerin. - Angina prophylaxis: decreases myocardial oxygen demand during physical activity.

Isosorbide Mononitrate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Headache - Dizziness - Flushing - Nausea

Serious or Rare Side Effects: - Severe hypotension - Syncope - Allergic reaction (e.g., rash, angioedema)

When prescribing Isosorbide Mononitrate, clinicians should consider several safety measures. - Dose titration: start with a low dose and adjust based on tolerance. - Concomitant nitrates: avoid combined use due to risk of profound hypotension. - Phosphodiesterase‑5 inhibitors: use with caution because of additive blood‑pressure effects. - Renal impairment: monitor renal function and adjust dose if needed. - Pregnancy: safety not established; use only if benefit outweighs potential risk. - Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Isosorbide Mononitrate can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Other nitrates (e.g., nitroglycerin): risk of profound hypotension. - Phosphodiesterase‑5 inhibitors (e.g., sildenafil): risk of severe hypotension.

Moderate Interactions (Monitor Closely): - Antihypertensives: additive blood‑pressure lowering effect. - Diuretics: may increase risk of hypotension. - Alcohol: can enhance vasodilatory responses and dizziness.