Mononit 60 Retard (Isosorbide Mononitrate)

Isosorbide Mononitrate, the active ingredient in Mononit 60 Retard, is a nitrate (vasodilator) presented as a 60 mg extended‑release tablet for oral use. It treats angina pectoris and chronic stable angina by improving myocardial oxygen supply.

GNH USA supplies Mononit 60 Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Isosorbide Mononitrate is employed in the management of coronary artery disease‑related angina. - Angina pectoris prophylaxis: reduces frequency of chest pain episodes in patients with established angina. - Chronic stable angina: improves exercise tolerance and decreases symptom burden during daily activities. - Exercise‑induced angina: helps prevent angina attacks triggered by physical exertion.

Isosorbide Mononitrate may cause a range of adverse reactions, which are classified by frequency and severity.

Common Side Effects: - Headache: throbbing pain often occurring shortly after dosing. - Dizziness: light‑headed sensation, especially when standing quickly. - Flushing: warm, reddening of the face or neck. - Nausea: mild stomach upset or urge to vomit. - Hypotension: lower than normal blood pressure causing faintness.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure leading to syncope. - Reflex tachycardia: rapid heart rate in response to vasodilation. - Myocardial infarction: rare occurrence of heart attack. - Allergic reaction: rash, itching, swelling, or difficulty breathing.

Before prescribing Mononit 60 Retard, clinicians should consider several precautionary measures to ensure safe use. - Assess cardiovascular status: evaluate blood pressure and heart rate prior to initiation. - Avoid concurrent PDE‑5 inhibitors: co‑administration can cause profound hypotension. - Monitor for tolerance development: efficacy may diminish with prolonged use. - Adjust dose in renal impairment: consider reduced dosing in patients with decreased renal function. - Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Isosorbide Mononitrate interacts with several drug classes; awareness of these interactions helps prevent adverse events.

Major Interactions (Avoid): - Sildenafil and other PDE‑5 inhibitors: may cause severe hypotension. - Other nitrates (e.g., nitroglycerin): additive vasodilatory effect leading to dangerous blood‑pressure drops. - Antihypertensive agents (e.g., ACE inhibitors, beta‑blockers): can enhance blood‑pressure‑lowering effects.

Moderate Interactions (Monitor Closely): - Diuretics: may increase risk of orthostatic hypotension. - Alcohol: can potentiate vasodilatory effects and dizziness. - Azole antifungals (e.g., ketoconazole): may raise plasma concentrations of isosorbide mononitrate.