Mononit 100 Retard (Isosorbide Mononitrate)

Isosorbide Mononitrate, the active ingredient in Mononit 100 Retard, is a organic nitrate presented as a 100 mg extended‑release tablet for oral use. It treats chronic stable angina, angina pectoris and heart failure in adults.

GNH USA supplies Mononit 100 Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Isosorbide mononitrate is employed in the management of coronary artery disease and related conditions.

- Chronic stable angina: reduces the frequency of angina attacks and improves exercise tolerance. - Angina pectoris: alleviates chest‑pain episodes by enhancing myocardial oxygen supply. - Heart failure: decreases cardiac preload and afterload, helping to relieve symptoms of congestive heart failure.

Adverse reactions may occur with any nitrate therapy.

Common Side Effects: - Headache: mild to moderate throbbing pain, often transient. - Dizziness or light‑headedness: related to blood pressure lowering. - Flushing: warm sensation and reddening of skin. - Nausea: occasional upset stomach. - Palpitations: awareness of heartbeat. - Hypotension: mild drop in blood pressure.

Serious or Rare Side Effects: - Severe hypotension: marked blood pressure fall requiring medical attention. - Syncope: sudden loss of consciousness. - Allergic reactions: rash, itching, swelling, or anaphylaxis. - Methemoglobinemia: rare blood disorder causing cyanosis.

Patients should be counseled on safety considerations before starting therapy.

- Dose adjustment in renal impairment: reduce dose or monitor renal function closely. - Avoid use with phosphodiesterase‑5 inhibitors: risk of profound hypotension. - Monitor blood pressure regularly: watch for symptomatic hypotension. - Use cautiously in patients with anemia or low baseline blood pressure. - Discontinue before surgery: to reduce peri‑operative hypotension risk. - Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Isosorbide mononitrate can interact with several drug classes.

Major Interactions (Avoid): - Sildenafil and other PDE‑5 inhibitors: may cause severe hypotension. - Other organic nitrates (e.g., nitroglycerin): additive vasodilatory effect. - Antihypertensive agents (ACE inhibitors, beta‑blockers, calcium channel blockers): may enhance blood‑pressure lowering.

Moderate Interactions (Monitor Closely): - Diuretics: may increase risk of hypotension. - Alcohol: can augment vasodilatory effects and dizziness. - Azole antifungals (e.g., ketoconazole): may raise plasma levels of isosorbide mononitrate.