Moklar (Moclobemide)

Moclobemide, the active ingredient in Moklar, is a reversible monoamine oxidase inhibitor (RIMA) presented as an oral dosage form for oral use. It is indicated for the treatment of major depressive disorder and dysthymia in adult patients. GNH USA supplies Moklar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Moclobemide acts on depressive disorders by reversibly inhibiting MAO‑A, thereby increasing monoamine neurotransmitters. - Major depressive disorder: reduces depressive symptoms and improves mood. - Dysthymia: alleviates persistent low‑grade depression and enhances functional capacity.

Moclobemide may cause a range of adverse reactions, most of which are mild and dose‑related.

Common Side Effects: - Nausea - Headache - Insomnia - Dizziness

Serious or Rare Side Effects: - Hypertensive crisis (especially with high‑tyramine foods) - Serotonin syndrome when combined with other serotonergic agents

Before initiating therapy, clinicians should evaluate individual risk factors and contraindications. - Assess hepatic function: adjust use if liver impairment is present. - Avoid tyramine‑rich foods: reduce risk of hypertensive reactions. - Review concomitant serotonergic drugs: prevent serotonin syndrome. - Monitor blood pressure regularly during treatment. - Store at ambient temperature: keep in the original pack, protect from moisture.

Moclobemide can interact with several medication classes, requiring careful management.

Major Interactions (Avoid): - Tyramine‑rich foods and beverages (e.g., aged cheeses, cured meats). - Serotonergic agents such as SSRIs, SNRIs, tramadol, and other MAO inhibitors. - Meperidine and other opioid analgesics.

Moderate Interactions (Monitor Closely): - Non‑steroidal anti‑inflammatory drugs (NSAIDs). - Warfarin and other anticoagulants.