GNH USA

Europe — EMA

Moduxin Mr (Trimetazidine Dihydrochloride)

GNH USA supplies Moduxin Mr (Trimetazidine), a metabolic modulator for chronic stable angina, coronary artery disease and peripheral arterial disease.

Trimetazidine Dihydrochloride

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What is Trimetazidine Dihydrochloride?

Trimetazidine, the active ingredient in Moduxin Mr, is a metabolic modulator (anti‑ischemic agent) presented as an oral dosage form for systemic use. It is prescribed to improve myocardial efficiency in patients with chronic stable angina, coronary artery disease, and peripheral arterial disease.

GNH USA supplies Moduxin Mr as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Trimetazidine Dihydrochloride used for?

Moduxin Mr is used as an anti‑ischemic agent to manage conditions where myocardial oxygen supply is limited.

- Chronic stable angina pectoris: reduces frequency of angina attacks and improves exercise tolerance. - Coronary artery disease: enhances cardiac metabolic efficiency during ischemic episodes. - Peripheral arterial disease: alleviates intermittent claudication by improving muscle oxygen utilization.

What are the side effects of Trimetazidine Dihydrochloride?

Adverse reactions may occur with Trimetazidine therapy.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Headache: transient cranial discomfort. - Dizziness: sensation of light‑headedness, especially on standing. - Gastrointestinal discomfort: abdominal pain or dyspepsia. - Skin rash: mild erythematous eruptions.

Serious or Rare Side Effects: - Parkinsonian symptoms: tremor, rigidity, or bradykinesia. - Severe allergic reaction: anaphylaxis, angioedema, or bronchospasm. - Hepatic dysfunction: elevated liver enzymes or jaundice. - Hematologic abnormalities: leukopenia or thrombocytopenia.

What precautions apply to Trimetazidine Dihydrochloride?

Before initiating therapy, consider the following precautions.

- Renal impairment: adjust use in patients with severe kidney dysfunction. - Hepatic disease: monitor liver function tests regularly. - Neurological disorders: avoid in patients with Parkinson's disease or movement disorders. - Pregnancy and lactation: use only if the potential benefit justifies the potential risk. - Concomitant anti‑arrhythmic drugs: monitor for additive cardiac effects. - Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and direct sunlight.

What does Trimetazidine Dihydrochloride interact with?

Trimetazidine may interact with other medicines; awareness of interaction severity is essential.

Major Interactions (Avoid): - Antiparkinsonian agents: may exacerbate movement disorders. - Strong CYP2D6 inhibitors: could increase plasma levels of Trimetazidine.

Moderate Interactions (Monitor Closely): - Antihypertensive drugs: additive blood pressure lowering effect. - Diuretics: monitor electrolyte balance and renal function. - Other anti‑ischemic agents: assess for overlapping therapeutic effects and side‑effect profiles.

Frequently asked questions

What is Moduxin Mr used for?+
Moduxin Mr contains Trimetazidine, a metabolic modulator indicated for chronic stable angina, coronary artery disease, and peripheral arterial disease. It helps improve heart muscle efficiency during episodes of reduced oxygen supply.
How does Trimetazidine work in the body?+
Trimetazidine inhibits mitochondrial long‑chain 3‑ketoacyl‑CoA thiolase, shifting heart muscle energy production from fatty‑acid oxidation to glucose oxidation. This change requires less oxygen for the same amount of ATP, enhancing cardiac performance under ischemic conditions.
What is the usual dose of Moduxin Mr?+
The specific dose of Moduxin Mr is determined by the prescribing clinician based on the patient’s condition, severity, and response to therapy. Dosage adjustments are made according to individual therapeutic needs.
Is Moduxin Mr safe during pregnancy or breastfeeding?+
Safety data for Trimetazidine in pregnancy and lactation are limited. It should only be used if the potential benefit outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.
How do I order Moduxin Mr from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.
How does Moduxin Mr compare with other anti‑anginal drugs?+
Unlike nitrates or calcium‑channel blockers that primarily dilate vessels, Trimetazidine acts at the cellular level to improve myocardial metabolism. This distinct mechanism can be complementary to other anti‑anginal agents, offering an alternative for patients who need metabolic support.
What are the storage requirements for Moduxin Mr?+
Store Moduxin Mr at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture, heat, and direct sunlight to maintain product stability.
How is Moduxin Mr administered?+
Moduxin Mr is taken orally, usually with or without food, as directed by the prescribing physician. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.
What are the most serious risks associated with Moduxin Mr?+
Serious adverse reactions, though rare, include Parkinsonian symptoms such as tremor or rigidity, severe allergic responses like anaphylaxis, and significant liver enzyme elevations. Patients should seek immediate medical attention if these occur.
Who should not use Moduxin Mr?+
Moduxin Mr is contraindicated in patients with known hypersensitivity to Trimetazidine or any excipients, and it should be avoided in individuals with Parkinson’s disease or other movement disorders due to the risk of symptom aggravation.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Trimetazidine Dihydrochloride
Route
Oral Use
Manufacturer
Gedeon Richter România S.A.
Origin
EU

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