GNH USA

Europe — EMA

Modopar L.P. 125 (Benserazide Hydrochloride, Levodopa)

GNH USA supplies Modopar L.P. 125 (Levodopa/Benserazide), a dopamine precursor and dopa decarboxylase inhibitor for Parkinson's disease and Parkinsonian

Benserazide Hydrochloride, Levodopa

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What is Benserazide Hydrochloride, Levodopa?

Levodopa, the active ingredient in Modopar L.P. 125, is a dopamine precursor presented as a Levodopa 100 mg / Benserazide 25 mg tablet for oral use. It treats Parkinson's disease and Parkinsonian syndrome in adults.

GNH USA supplies Modopar L.P. 125 as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Benserazide Hydrochloride, Levodopa used for?

Modopar L.P. 125 is used in the management of Parkinsonian disorders by restoring central dopaminergic activity.

Parkinson's disease: improves motor function, reduces tremor and rigidity. Parkinsonian syndrome: alleviates bradykinesia and gait disturbances. Levodopa‑responsive movement disorders: provides symptomatic control of motor fluctuations.

What are the side effects of Benserazide Hydrochloride, Levodopa?

Adverse reactions may occur with Modopar L.P. 125 and are categorized by frequency.

Common Side Effects: - Nausea and vomiting - Orthostatic hypotension - Dizziness or light‑headedness - Insomnia or vivid dreams - Dyskinesia (involuntary movements) - Dry mouth

Serious or Rare Side Effects: - Hallucinations or psychosis - Severe dyskinesia affecting daily activities - Cardiac arrhythmias or sudden hypotensive episodes - Neuroleptic malignant‑like syndrome - Pulmonary edema - Severe allergic reactions (rash, swelling, anaphylaxis)

What precautions apply to Benserazide Hydrochloride, Levodopa?

When prescribing Modopar L.P. 125, clinicians should consider several safety measures.

Dose titration: start with a low dose and increase gradually to minimize side effects. Monitor for dyskinesia: watch for involuntary movements that may require dose adjustment. Assess renal and hepatic function: adjust therapy in patients with impairment. Avoid abrupt discontinuation: taper the dose to prevent withdrawal symptoms. Use with food: taking the tablet with meals can reduce gastrointestinal irritation. Store at ambient temperature: keep in the original pack, protect from moisture.

What does Benserazide Hydrochloride, Levodopa interact with?

Modopar L.P. 125 can interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid): - Non‑selective MAO inhibitors: risk hypertensive crisis. - Antipsychotics (e.g., haloperidol): block dopamine effect, reducing efficacy. - High‑dose pyridoxine (vitamin B6): decreases levodopa absorption.

Moderate Interactions (Monitor Closely): - Antihypertensives: may enhance orthostatic hypotension. - SSRIs or SNRIs: potential for serotonin syndrome. - Iron or calcium supplements: can reduce levodopa bioavailability if taken concurrently.

Frequently asked questions

What is Modopar L.P. 125 used for?+
Modopar L.P. 125 is prescribed to manage the motor symptoms of Parkinson's disease and Parkinsonian syndrome. By delivering levodopa and benserazide together, it helps restore dopamine levels in the brain, improving tremor, rigidity, and bradykinesia in affected patients.
How does levodopa work in Modopar L.P. 125?+
Levodopa is a precursor of dopamine that crosses the blood‑brain barrier. Once inside the central nervous system it is converted to dopamine, compensating for the loss of dopaminergic neurons characteristic of Parkinsonian disorders. Benserazide prevents peripheral conversion, ensuring more levodopa reaches the brain.
What is the usual dose of Modopar L.P. 125?+
The appropriate dose of Modopar L.P. 125 is individualized by the prescribing clinician based on disease severity, patient response, and tolerability. Dosage adjustments are made gradually to balance symptom control with potential side effects, and patients should follow their doctor's specific instructions.
Is Modopar L.P. 125 safe during pregnancy or breastfeeding?+
The safety of Modopar L.P. 125 in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.
How do I order Modopar L.P. 125 from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.
How does Modopar L.P. 125 compare with other Parkinson's medications?+
Modopar L.P. 125 combines levodopa with benserazide, offering higher central availability of levodopa compared with levodopa alone. Compared with other combination products (e.g., levodopa/carbidopa), the clinical efficacy is similar, but individual tolerability and side‑effect profiles may differ, influencing the choice of therapy.
What are the storage requirements for Modopar L.P. 125?+
Store Modopar L.P. 125 tablets at ambient temperature, below 25 °C, in the original container. Protect the tablets from moisture and direct sunlight to maintain stability and potency throughout the shelf life.
How is Modopar L.P. 125 administered?+
Modopar L.P. 125 is taken orally with a glass of water, usually with meals to lessen gastrointestinal upset. The tablet should be swallowed whole and not split, chewed, or crushed unless specifically instructed by a healthcare professional.
What are the most serious risks associated with Modopar L.P. 125?+
Serious risks include the development of severe dyskinesia, hallucinations or psychosis, and cardiovascular events such as marked hypotension or arrhythmias. Patients should be monitored closely for these reactions, and any concerning symptoms should prompt immediate medical evaluation.
Who should not use Modopar L.P. 125?+
Modopar L.P. 125 is contraindicated in patients with known hypersensitivity to levodopa, benserazide, or any excipients in the tablet. It should also be avoided in individuals taking non‑selective MAO inhibitors or those with narrow‑angle glaucoma, unless directed by a specialist.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Benserazide Hydrochloride, Levodopa
Route
Oral Use
Manufacturer
Roche
Origin
EU

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