GNH USA

Europe — EMA

Modopar 62,5 (Benserazide Hydrochloride, Levodopa)

GNH USA supplies Modopar 62,5 (Levodopa/Benserazide), a dopamine precursor for Parkinson's disease and Parkinsonian syndrome.

Benserazide Hydrochloride, Levodopa

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What is Benserazide Hydrochloride, Levodopa?

Levodopa/Benserazide, the active ingredient in Modopar 62,5, is a dopamine precursor/dopa decarboxylase inhibitor presented as a 62.5 mg oral tablet for oral use. It treats Parkinson's disease and related Parkinsonian syndromes in adult patients.

GNH USA supplies Modopar 62,5 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Benserazide Hydrochloride, Levodopa used for?

Modopar 62,5, a combination of levodopa and benserazide, is used in the management of Parkinsonian disorders by restoring central dopamine levels.

Parkinson's disease: improves motor symptoms such as tremor, rigidity and bradykinesia. Parkinsonian syndrome: alleviates motor deficits associated with the syndrome. Secondary Parkinsonism: provides symptomatic relief when caused by drug‑induced or vascular factors.

What are the side effects of Benserazide Hydrochloride, Levodopa?

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Orthostatic hypotension: dizziness upon standing. - Headache: transient cranial discomfort. - Insomnia: difficulty initiating or maintaining sleep. - Dyskinesia: involuntary movements, especially at higher doses. - Dry mouth: reduced salivation.

Serious or Rare Side Effects: - Severe hypotension: marked blood pressure drop requiring medical attention. - Psychosis or hallucinations: visual or auditory disturbances. - Cardiac arrhythmias: irregular heart rhythms in susceptible individuals. - Neuroleptic malignant syndrome: rare but life‑threatening reaction. - Severe dyskinesia: disabling involuntary movements.

What precautions apply to Benserazide Hydrochloride, Levodopa?

Before initiating therapy, clinicians should consider several safety aspects. - Monitor blood pressure: check for orthostatic changes, especially after dose adjustments. - Assess for dyskinesia: observe for involuntary movements during follow‑up. - Review psychiatric status: watch for hallucinations or mood changes. - Avoid abrupt discontinuation: taper under medical supervision to prevent withdrawal. - Store at ambient temperature: keep in the original pack, protect from moisture and light.

What does Benserazide Hydrochloride, Levodopa interact with?

Levodopa/benserazide may interact with several medicines; careful review is essential. Major Interactions (Avoid): - Non‑selective MAO inhibitors: risk of hypertensive crisis. - Antipsychotics (dopamine antagonists): may diminish therapeutic effect. - High‑dose pyridoxine (vitamin B6): accelerates peripheral levodopa metabolism. Moderate Interactions (Monitor Closely): - Antihypertensive agents: additive blood‑pressure lowering. - SSRIs or SNRIs: potential for serotonin syndrome. - Iron or calcium supplements: may reduce levodopa absorption if taken simultaneously.

Frequently asked questions

What is Modopar 62,5 used for?+
Modopar 62,5 is prescribed to manage the motor symptoms of Parkinson's disease and Parkinsonian syndrome. It works by increasing dopamine levels in the brain, helping to reduce tremor, stiffness, and slowness of movement in adult patients.
How does Levodopa/Benserazide work?+
Levodopa is a dopamine precursor that crosses the blood‑brain barrier and is converted to dopamine in the central nervous system. Benserazide inhibits the peripheral enzyme dopa decarboxylase, preventing premature conversion of levodopa outside the brain and thereby enhancing its central availability.
What is the usual dose of Modopar 62,5?+
The specific dose of Modopar 62,5 is determined by the prescribing clinician based on the individual’s disease severity, response to therapy, and tolerability. Patients should follow the dosage instructions provided by their healthcare professional.
Is Modopar 62,5 safe during pregnancy or breastfeeding?+
The safety of Modopar 62,5 in pregnancy or while breastfeeding has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.
How do I order Modopar 62,5 from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Modopar 62,5 compare with other antiparkinson agents?+
Modopar 62,5 combines levodopa with benserazide, offering a direct dopamine replacement strategy. Compared with dopamine agonists, it generally provides more robust symptom control but may have a higher risk of motor complications such as dyskinesia. Choice of therapy depends on individual patient factors and physician judgment.
What are the storage and handling requirements for Modopar 62,5?+
Store Modopar 62,5 tablets at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.
How is Modopar 62,5 administered?+
Modopar 62,5 is taken orally, usually with a glass of water. It may be taken with or without food, but consistent timing relative to meals can help minimize gastrointestinal side effects. Patients should follow the dosing schedule prescribed by their clinician.
What are the most serious risks associated with Modopar 62,5?+
Serious risks include severe hypotension, neuroleptic malignant syndrome, significant dyskinesia, and psychiatric disturbances such as hallucinations or psychosis. Patients should be monitored closely for these events, and any sudden or severe symptoms should prompt immediate medical evaluation.
Who should not use Modopar 62,5?+
Modopar 62,5 is contraindicated in patients with known hypersensitivity to levodopa, benserazide, or any excipients, and in those taking non‑selective MAO inhibitors. Caution is also advised for individuals with a history of severe cardiovascular disease, uncontrolled hypertension, or psychiatric disorders.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Benserazide Hydrochloride, Levodopa
Route
Oral Use
Manufacturer
Roche
Origin
EU

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