Modolex (Calcium Dobesilate Monohydrate, Lidocaine Hydrochloride)

Calcium Dobesilate Monohydrate, the active ingredient in Modolex, is a vasoprotective agent presented as a rectal formulation for local administration. It is combined with Lidocaine Hydrochloride, a local anesthetic, to address hemorrhoidal disease, anal fissures, and other microvascular disorders by reducing capillary permeability and providing analgesia.

GNH USA supplies Modolex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality, regulatory compliance and reliable logistics for global distribution.

Modolex combines a vasoprotective agent with a local anesthetic to treat conditions involving impaired microcirculation and pain in the anorectal region.

- Hemorrhoids: reduces swelling and bleeding while providing local pain relief. - Anal fissure: improves microvascular blood flow and eases discomfort during defecation. - Microvascular disorders: enhances capillary stability and mitigates associated pain.

Adverse reactions may occur following rectal administration of Modolex.

Common Side Effects: - Mild rectal irritation or burning sensation. - Transient pruritus around the application site. - Light‑headedness or mild headache. - Nausea without vomiting. - Temporary increase in bowel movements.

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis) with swelling, rash or difficulty breathing. - Persistent or worsening rectal bleeding. - Ulceration or necrosis of the rectal mucosa. - Systemic lidocaine toxicity presenting as dizziness, tinnitus or cardiac arrhythmia. - Vasovagal syncope triggered by the rectal procedure.

Before using Modolex, consider the following safety measures.

- Pregnancy: safety not established; avoid unless the potential benefit outweighs the risk. - Breastfeeding: unknown excretion; use with caution. - Concomitant anticoagulants: monitor for increased bleeding. - Active rectal infection or severe inflammation: contraindicated until resolved. - Known hypersensitivity to calcium dobesilate, lidocaine or any excipients: discontinue immediately. - Store at ambient temperature: keep in the original packaging, protect from moisture and light.

Modolex may interact with other medicines; monitor accordingly.

Major Interactions (Avoid): - Systemic local anesthetics: risk of cumulative lidocaine toxicity. - Anticoagulants (e.g., warfarin, DOACs): heightened bleeding tendency. - Other vasoprotective agents: additive effects on capillary permeability.

Moderate Interactions (Monitor Closely): - NSAIDs: may increase gastrointestinal irritation. - Antihistamines: can potentiate local anesthetic effect. - Alcohol: may exacerbate dizziness or sedation.