Modifenac (Diclofenac Sodium)

Diclofenac Sodium, the active ingredient in Modifenac, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral formulation for systemic use. It is employed to relieve pain and reduce inflammation in conditions such as osteoarthritis and rheumatoid arthritis, particularly in adult patients requiring symptomatic management.

GNH USA supplies Modifenac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. All shipments are accompanied by full regulatory documentation.

Modifenac, a diclofenac‑based NSAID, acts on inflammatory pathways to alleviate symptoms in several musculoskeletal conditions.

Pain: Provides symptomatic relief of mild to moderate pain. Inflammation: Reduces swelling and inflammatory response in affected tissues. Osteoarthritis: Improves joint function and decreases pain associated with osteoarthritis. Rheumatoid arthritis: Helps control pain and inflammation in rheumatoid arthritis flares.

Adverse reactions to Modifenac may vary in frequency and severity.

Common Side Effects: - Gastrointestinal discomfort such as dyspepsia or nausea. - Headache. - Dizziness. - Elevated liver enzymes.

Serious or Rare Side Effects: - Peptic ulcer disease or gastrointestinal bleeding. - Severe skin reactions, for example Stevens‑Johnson syndrome. - Hepatotoxicity or significant liver injury. - Renal impairment or acute kidney injury.

When prescribing Modifenac, clinicians should consider several precautionary measures to minimise risk.

Assess gastrointestinal risk: evaluate history of ulcers, bleeding or NSAID use. Monitor liver function: perform baseline and periodic liver enzyme tests. Check renal function: assess creatinine clearance before and during therapy. Avoid in patients with known hypersensitivity to diclofenac or other NSAIDs. Store at ambient temperature below 25°C: keep in original packaging, protect from moisture.

Modifenac can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - Selective serotonin reuptake inhibitors (SSRIs) or other serotonergic agents: heightened bleeding risk.

Moderate Interactions (Monitor Closely): - ACE inhibitors or diuretics: may reduce renal function, monitor kidney parameters. - Lithium: diclofenac can increase lithium levels, monitor serum concentration. - Methotrexate: reduced clearance may raise toxicity, monitor hepatic and renal function.