Modifenac (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Modifenac, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It is employed to relieve mild to moderate pain and to reduce inflammation in conditions such as osteoarthritis, rheumatoid arthritis and post‑operative states. GNH USA supplies Modifenac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Modifenac, a diclofenac‑based NSAID, is indicated for several inflammatory and pain‑related conditions. - Mild to moderate pain: provides analgesic relief for everyday aches. - Osteoarthritis: reduces joint inflammation and improves mobility. - Rheumatoid arthritis: helps control chronic joint inflammation and pain. - Musculoskeletal pain: eases strain‑related discomfort in muscles and tendons. - Post‑operative pain: assists in managing pain after surgical procedures.

Adverse reactions may occur with any NSAID, including diclofenac.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain. - Headache: mild to moderate intensity. - Dizziness or vertigo. - Skin reactions: rash or mild itching. - Elevated liver enzymes: transient laboratory changes.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Severe hepatic injury or jaundice. - Renal impairment or acute kidney injury. - Cardiovascular events such as myocardial infarction or stroke. - Severe skin reactions like Stevens‑Johnson syndrome.

Before using Modifenac, consider the following safety measures. - Cardiovascular risk: avoid in patients with recent myocardial infarction or uncontrolled hypertension. - Gastrointestinal history: use cautiously in those with ulcer disease or prior GI bleeding. - Renal function: monitor kidney parameters in patients with chronic kidney disease. - Hepatic status: check liver function tests regularly for long‑term therapy. - Concomitant drugs: review all current medications for potential interactions. - Store at ambient temperature: keep below 25°C in the original container, protected from moisture and direct sunlight.

Diclofenac can affect the safety or effectiveness of several other medicines.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - Selective serotonin reuptake inhibitors (SSRIs): heightened gastrointestinal bleeding risk.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may reduce renal function, especially in volume‑depleted patients. - Lithium: diclofenac can raise lithium levels, requiring serum monitoring. - Methotrexate: possible increase in methotrexate toxicity at high doses.