Modamide (Amiloride Hydrochloride Dihydrate)

Amiloride, the active ingredient in Modamide, is a potassium-sparing diuretic presented as an oral tablet for oral use. It treats hypertension, edema associated with congestive heart failure, and nephrotic syndrome in adult patients.

GNH USA supplies Modamide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Modamide is a potassium‑sparing diuretic used in conditions where sodium retention contributes to fluid overload. - Hypertension: helps lower blood pressure by reducing sodium reabsorption while preserving potassium. - Congestive heart‑failure edema: decreases fluid accumulation in the lungs and peripheral tissues. - Nephrotic syndrome: limits protein‑loss‑related edema by promoting modest diuresis without worsening potassium loss.

Adverse reactions may occur with any medication and should be monitored by the prescriber.

Common Side Effects: - Dizziness - Headache - Nausea or upset stomach - Fatigue - Muscle cramps - Mild hyperkalemia (elevated potassium)

Serious or Rare Side Effects: - Severe hyperkalemia leading to cardiac arrhythmia - Acute renal impairment - Significant hypotension - Allergic skin reactions (rash, urticaria) - Metabolic acidosis - Pulmonary edema in rare cases

Before initiating therapy, clinicians should assess patient‑specific factors and monitor relevant parameters. - Monitor serum potassium: avoid excessive accumulation, especially with other potassium‑sparing agents. - Assess renal function: dose adjustment may be required in reduced clearance. - Use caution in diabetic patients: potassium shifts can affect glucose control. - Avoid in severe renal impairment unless benefits outweigh risks. - Adjust dose in elderly patients due to altered pharmacodynamics. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Amiloride can affect the pharmacodynamics of several co‑administered drugs.

Major Interactions (Avoid): - ACE inhibitors or ARBs: may cause dangerous hyperkalemia. - Other potassium‑sparing diuretics (e.g., spironolactone): increase risk of severe hyperkalemia. - Potassium supplements or salt substitutes containing potassium. - Trimethoprim: additive effect on potassium levels. - Lithium: may increase lithium toxicity.

Moderate Interactions (Monitor Closely): - NSAIDs: can reduce diuretic efficacy and impair renal function. - Thiazide diuretics: may cause additive electrolyte disturbances. - Digoxin: altered serum potassium can affect digoxin toxicity. - Corticosteroids: may counteract diuretic effect. - Antidiabetic agents: potassium shifts may influence glucose control.