GNH USA

Europe — EMA

Mizodin (Primidone)

GNH USA supplies Mizodin (Primidone), a barbiturate anticonvulsant for generalized tonic‑clonic and partial seizures. Request a quote for global supply.

Primidone

Request sourcing

1
Pack/s

What is Primidone?

Primidone, the active ingredient in Mizodin, is a barbiturate anticonvulsant presented as an oral tablet for oral use. It is employed to control generalized tonic‑clonic seizures and partial seizures in patients requiring seizure management.

GNH USA supplies Mizodin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Primidone used for?

Mizodin is an anticonvulsant medication used to treat seizure disorders within the epilepsy disease family.

- Generalized tonic‑clonic seizures: reduces the frequency and severity of convulsive episodes. - Partial seizures: helps control focal seizure activity and prevents progression. - Epilepsy (adjunct therapy): provides additional seizure control when used with other antiepileptic drugs.

What are the side effects of Primidone?

Mizodin may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Dizziness - Drowsiness or fatigue - Nausea or gastrointestinal upset - Ataxia or unsteady gait - Blurred vision - Headache

Serious or Rare Side Effects: - Severe skin reactions such as Stevens‑Johnson syndrome - Blood dyscrasias including agranulocytosis - Respiratory depression, especially with CNS depressants - Suicidal thoughts or mood changes - Hepatic dysfunction or jaundice - Life‑threatening allergic reactions (anaphylaxis).

What precautions apply to Primidone?

Before initiating Mizodin, several safety considerations should be reviewed.

- Renal impairment: adjust dose and monitor renal function. - Hepatic impairment: use with caution and assess liver enzymes. - Concomitant CNS depressants: increased risk of sedation and respiratory depression. - Pregnancy: potential risk unknown; discuss benefits and risks with a healthcare professional. - Elderly patients: heightened sensitivity to sedative effects; start at lower doses. - Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

What does Primidone interact with?

Mizodin can interact with other medicines, requiring careful management.

Major Interactions (Avoid): - Phenobarbital: additive central nervous system depression. - Alcohol: potentiates sedative effects and respiratory depression. - Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase primidone plasma concentrations.

Moderate Interactions (Monitor Closely): - Carbamazepine: may reduce primidone efficacy. - Valproic acid: may increase risk of adverse CNS effects. - Oral contraceptives: may experience reduced hormonal effectiveness.

Frequently asked questions

What is Mizodin used for?+
Mizodin is prescribed to manage epilepsy, specifically for patients with generalized tonic‑clonic seizures and partial (focal) seizures. It may be used as monotherapy or as an adjunct to other antiepileptic drugs to improve overall seizure control.
How does Primidone work?+
Primidone is converted in the body to phenobarbital, which enhances the activity of the inhibitory neurotransmitter GABA. This increased GABAergic inhibition reduces neuronal excitability, helping to prevent the abnormal electrical activity that leads to seizures.
What is the usual dose of Mizodin?+
The appropriate dose of Mizodin is determined individually by a prescribing healthcare professional based on the patient’s age, weight, seizure type, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.
Is Mizodin safe during pregnancy or breastfeeding?+
Safety data for Mizodin in pregnancy and lactation are limited. The potential risks and benefits should be evaluated by a qualified clinician. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternative options or close monitoring with their doctor.
How do I order Mizodin from GNH USA?+
To order Mizodin, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.
How does Mizodin compare with the main alternative drug or class?+
Mizodin (primidone) is often compared with phenobarbital, another barbiturate anticonvulsant. Both share a similar mechanism, but primidone may have a slightly different side‑effect profile and is sometimes preferred for its once‑daily dosing. Compared with newer agents such as levetiracetam, primidone is less expensive but may cause more sedation.
How should Mizodin be stored and handled?+
Mizodin tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged or the tablets appear discolored.
How is Mizodin administered?+
Mizodin is taken orally, usually with a glass of water. It can be taken with or without food, but consistent administration with respect to meals helps maintain stable blood levels. Patients should swallow the tablet whole and not crush or chew it unless instructed otherwise.
What are the most serious risks to watch for while taking Mizodin?+
Serious risks include severe skin reactions (e.g., Stevens‑Johnson syndrome), blood disorders such as agranulocytosis, respiratory depression especially when combined with other CNS depressants, and significant liver dysfunction. Any signs of rash, fever, unusual bleeding, or breathing difficulties should prompt immediate medical attention.
Who should not use Mizodin?+
Mizodin is contraindicated in patients with known hypersensitivity to primidone, phenobarbital, or any barbiturate components. It should also be avoided in individuals with severe hepatic impairment or those taking medications that could cause life‑threatening interactions without close monitoring.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Primidone
Route
Oral Use
Manufacturer
Zakłady Farmaceutyczne „unia” Spółdzielnia Pracy
Origin
EU

Related products

Primidone 250 mg/1

Primidone 250 mg/1

Primidone · 250 mg

Primidone
TABLET
Lannett Company, Inc.
USA
Primidone 250 mg/1

Primidone 250 mg/1

Primidone · 250 mg

Primidone
TABLET
Lannett Company, Inc.
USA
Primidone 250 mg/1

Primidone 250 mg/1

Primidone · 250 mg

Primidone
TABLET
Lannett Company, Inc.
USA
Primidone 50 mg/1

Primidone 50 mg/1

Primidone · 50 mg

Primidone
TABLET
Lannett Company, Inc.
USA