Mistra (Dienogest, Ethinylestradiol)

Dienogest/Ethinylestradiol, the active ingredient in Mistra, is a combined oral contraceptive presented as an oral tablet for oral use. It works by inhibiting ovulation and inducing cervical mucus changes to prevent fertilisation, providing reliable pregnancy prevention for women of reproductive age. The formulation is approved for use in the European Union and follows standard dosing regimens under medical supervision.

GNH USA supplies Mistra as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide with a focus on quality assurance and regulatory compliance.

Mistra is a combined oral contraceptive that acts on the hormonal regulation of the menstrual cycle to prevent pregnancy. - Contraception: prevents unintended pregnancy in women of childbearing potential. - Menstrual cycle regulation: helps achieve regular monthly bleeding patterns. - Dysmenorrhea management: reduces menstrual pain and associated symptoms.

Mistra may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Headache: tension‑type or migraine‑like pain. - Breast tenderness: temporary swelling or discomfort. - Breakthrough bleeding: spotting between periods. - Weight gain: modest increase in body weight. - Mood changes: irritability or mood swings.

Serious or Rare Side Effects: - Venous thromboembolism: deep‑vein clot or pulmonary embolism. - Arterial thrombosis: heart attack or stroke. - Hepatic adenoma: benign liver tumor. - Severe hypertension: sudden rise in blood pressure. - Allergic reaction: rash, swelling, or anaphylaxis. - Visual disturbances: sudden loss of vision or eye pain.

Before starting Mistra, patients should consider several safety aspects. - Assess cardiovascular risk: evaluate history of clotting disorders, smoking, or hypertension. - Review liver function: avoid use in active liver disease or tumors. - Check for estrogen‑dependent cancers: contraindicated in known or suspected cases. - Monitor for migraine with aura: increased stroke risk. - Counsel on smoking cessation: especially for women over 35. - Store at below 25°C: keep in the original pack, protect from moisture and direct sunlight.

Mistra can interact with other medicines, altering its effectiveness or increasing risk.

Major Interactions (Avoid): - Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce contraceptive efficacy. - Anticoagulants (e.g., warfarin): may enhance anticoagulant effect.

Moderate Interactions (Monitor Closely): - Antiepileptics (e.g., phenytoin, phenobarbital): may modestly lower hormone levels. - Antiretrovirals (e.g., efavirenz): may decrease contraceptive reliability. - Herbal supplements (e.g., St. John’s wort): potential reduction in hormone concentrations.