GNH USA

Europe — EMA

Misofenac (Diclofenac Sodium, Misoprostol)

GNH USA supplies Misofenac (Diclofenac Sodium / Misoprostol), a nonsteroidal anti-inflammatory and gastroprotective drug for musculoskeletal pain and ulcer

Diclofenac Sodium, Misoprostol

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What is Diclofenac Sodium, Misoprostol?

Diclofenac sodium / misoprostol, the active ingredient in Misofenac, is a nonsteroidal anti‑inflammatory drug and prostaglandin E1 analogue presented as an oral dosage form for oral use. It provides analgesic and anti‑inflammatory effects for musculoskeletal pain while simultaneously protecting the gastric mucosa in patients receiving chronic NSAID therapy. The combination is indicated for conditions such as osteoarthritis and rheumatoid arthritis, where inflammation and pain are prominent, and for prophylaxis against NSAID‑induced gastric ulceration.

GNH USA supplies Misofenac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Diclofenac Sodium, Misoprostol used for?

Misofenac combines a NSAID with a gastroprotective prostaglandin analogue and is used for pain, inflammation, and ulcer prevention in musculoskeletal disorders.

- Osteoarthritis: reduces joint pain and inflammation, improving function and mobility. - Rheumatoid arthritis: alleviates inflammatory joint pain and swelling, supporting daily activities. - Prevention of NSAID‑induced gastric ulcers: protects gastric mucosa in patients receiving chronic NSAID therapy.

What are the side effects of Diclofenac Sodium, Misoprostol?

Misofenac may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Abdominal pain - Dyspepsia - Nausea - Diarrhea - Headache - Dizziness

Serious or Rare Side Effects: - Gastrointestinal ulcer or bleeding - Severe liver injury (hepatotoxicity) - Acute renal failure or worsening renal function - Hypersensitivity reactions such as Stevens‑Johnson syndrome - Cardiovascular events (e.g., myocardial infarction, stroke)

What precautions apply to Diclofenac Sodium, Misoprostol?

Before prescribing Misofenac, clinicians should consider several precautionary measures to minimize risk.

- Assess cardiovascular risk: NSAIDs may increase the likelihood of thrombotic events. - Monitor renal function: diclofenac can reduce renal perfusion, especially in dehydrated patients. - Evaluate hepatic status: both agents may affect liver enzymes and require periodic testing. - Contraindicated in pregnancy: category X due to risk of fetal toxicity and premature closure of the ductus arteriosus. - Use with caution in the elderly: higher susceptibility to gastrointestinal and renal adverse effects. - Store at ambient temperature: keep below 25 °C, protect from moisture and light.

What does Diclofenac Sodium, Misoprostol interact with?

Misofenac can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - Concurrent NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity. - ACE inhibitors or ARBs: may impair renal function when combined with diclofenac.

Moderate Interactions (Monitor Closely): - Lithium: diclofenac may raise lithium serum concentrations. - Methotrexate: reduced clearance can lead to toxicity. - Corticosteroids: combined use heightens risk of gastric ulceration.

Frequently asked questions

What is Misofenac used for?+
Misofenac is prescribed to relieve pain and inflammation associated with musculoskeletal disorders such as osteoarthritis and rheumatoid arthritis. It is also used to protect the stomach lining in patients who require long‑term NSAID therapy, thereby reducing the risk of NSAID‑induced gastric ulcers.
How does diclofenac sodium / misoprostol work?+
Diclofenac sodium blocks cyclo‑oxygenase‑1 and cyclo‑oxygenase‑2, lowering prostaglandin production and thus reducing pain and inflammation. Misoprostol mimics prostaglandin E1, stimulating gastric mucus and bicarbonate secretion and improving mucosal blood flow, which together safeguard the stomach from NSAID‑related damage.
What is the usual dose of Misofenac?+
The appropriate dose of Misofenac is determined by the prescribing healthcare professional based on the individual’s medical condition, response to therapy, and other relevant factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.
Is Misofenac safe during pregnancy or breastfeeding?+
Misofenac is classified as pregnancy category X, meaning it is contraindicated during pregnancy because of potential fetal harm, including premature closure of the ductus arteriosus. Use while breastfeeding is not recommended unless the benefits outweigh the risks, and a healthcare provider should be consulted.
How do I order Misofenac from GNH USA?+
To order Misofenac, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The team then replies with pricing, availability, shipping details and any required import documentation.
How does Misofenac compare with other NSAID‑gastroprotective options?+
Misofenac uniquely combines diclofenac, a potent NSAID, with misoprostol, a prostaglandin E1 analogue that directly protects the gastric lining. Compared with NSAID‑only products, it offers comparable analgesic efficacy while providing built‑in ulcer prophylaxis, potentially reducing the need for separate proton‑pump inhibitors or H2 blockers.
How should Misofenac be stored and handled?+
Misofenac should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date indicated on the label.
How is Misofenac administered?+
Misofenac is taken orally, usually with a full glass of water. It may be taken with or without food, but patients who experience stomach upset are advised to take it with meals to lessen gastrointestinal discomfort.
What are the most serious risks to watch for while taking Misofenac?+
Serious risks include gastrointestinal bleeding or ulceration, severe liver injury, acute kidney impairment, hypersensitivity reactions such as Stevens‑Johnson syndrome, and cardiovascular events like heart attack or stroke. Patients should seek immediate medical attention if they notice signs such as black stools, jaundice, sudden swelling, or severe skin rash.
Who should not use Misofenac?+
Misofenac should be avoided in individuals with known hypersensitivity to diclofenac, misoprostol, or any component of the formulation. It is also contraindicated in pregnant women, patients with active peptic ulcer disease, severe heart failure, uncontrolled hypertension, and those taking certain interacting medications without close medical supervision.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Diclofenac Sodium, Misoprostol
Route
Oral Use
Manufacturer
Pfizer Italia S.R.L.
Origin
EU

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