GNH USA

Europe — EMA

Mirtazapin Actavis (Mirtazapine)

GNH USA supplies Mirtazapin Actavis (Mirtazapine), a NaSSA antidepressant for major depressive disorder. Request a quote for global supply worldwide.

Mirtazapine

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What is Mirtazapine?

Mirtazapine, the active ingredient in Mirtazapin Actavis, is a NaSSA presented as an oral tablet for buccal, oral, and sublingual use. It is prescribed for the treatment of major depressive disorder in adult patients.

GNH USA supplies Mirtazapin Actavis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Mirtazapine used for?

Mirtazapin Actavis (mirtazapine) acts on the central nervous system to alleviate depressive symptoms.

- Major depressive disorder: reduces depressive symptoms and improves mood in adult patients.

What are the side effects of Mirtazapine?

Mirtazapin Actavis may cause a range of adverse reactions.

Common Side Effects: - Sedation or drowsiness - Increased appetite and weight gain - Dry mouth - Constipation - Dizziness

Serious or Rare Side Effects: - Agranulocytosis or severe neutropenia - Suicidal thoughts or behavior, especially early in treatment - Serotonin syndrome when combined with other serotonergic agents - Severe allergic reactions such as Stevens‑Johnson syndrome - Hepatic dysfunction or jaundice

What precautions apply to Mirtazapine?

Before initiating therapy, clinicians should consider several safety factors.

- Hepatic function: assess liver enzymes and adjust if impairment is present - Suicidal ideation: monitor patients closely during the first weeks of treatment - Elderly patients: use caution due to increased risk of sedation and falls - Discontinuation: avoid abrupt cessation to reduce withdrawal symptoms - Pregnancy and lactation: safety unknown; prescribe only if benefits outweigh potential risks - Store at room temperature: keep in the original container, protect from moisture and light

What does Mirtazapine interact with?

Mirtazapin Actavis can interact with several medication classes.

Major Interactions (Avoid): - MAO inhibitors: risk of hypertensive crisis; avoid concurrent use - Other serotonergic agents (e.g., SSRIs, SNRIs, tramadol): risk of serotonin syndrome; avoid - Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may increase plasma mirtazapine levels; avoid

Moderate Interactions (Monitor Closely): - CNS depressants (alcohol, benzodiazepines, opioids): additive sedation; monitor - Antihistamines: increased drowsiness; monitor - Carbamazepine or other enzyme inducers: may reduce mirtazapine concentrations; monitor

Frequently asked questions

What is Mirtazapin Actavis used for?+
Mirtazapin Actavis contains the active ingredient mirtazapine and is prescribed to treat major depressive disorder in adult patients. It helps alleviate depressive symptoms such as low mood, loss of interest, and sleep disturbances by modulating neurotransmitter activity in the brain.
How does mirtazapine work?+
Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, which increases norepinephrine release, and by antagonizing postsynaptic 5‑HT2 and 5‑HT3 receptors. This dual action enhances the overall availability of norepinephrine and serotonin, neurotransmitters that play key roles in mood regulation.
What is the usual dose of Mirtazapin Actavis?+
The appropriate dose of Mirtazapin Actavis is determined by the prescribing clinician based on the individual patient's clinical condition, response to therapy, and tolerability. Dosage may be adjusted over time, and patients should follow the specific instructions provided by their healthcare professional.
Is Mirtazapin Actavis safe during pregnancy or breastfeeding?+
The safety of mirtazapine in pregnancy and lactation has not been definitively established. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.
How do I order Mirtazapin Actavis from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.
How does Mirtazapin Actavis compare with other antidepressants?+
Mirtazapin Actavis belongs to the NaSSA class, which differs from selective serotonin reuptake inhibitors (SSRIs) by also enhancing norepinephrine release and blocking certain serotonin receptors. This mechanism often results in a distinct side‑effect profile, such as higher rates of sedation and weight gain, but may be advantageous for patients who do not respond adequately to SSRIs.
How should Mirtazapin Actavis be stored and handled?+
Store the tablets at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged or the tablets appear discolored.
How is Mirtazapin Actavis administered?+
Mirtazapin Actavis is taken orally, and the tablets can be swallowed whole, placed under the tongue (sublingual), or held in the buccal cavity before swallowing, depending on the prescriber's instructions. It is usually taken once daily, preferably in the evening to take advantage of its sedative effect.
What are the most serious risks associated with Mirtazapin Actavis?+
Serious risks include the potential for agranulocytosis or severe neutropenia, emergence or worsening of suicidal thoughts especially early in treatment, serotonin syndrome when combined with other serotonergic drugs, severe allergic reactions such as Stevens‑Johnson syndrome, and hepatic dysfunction. Patients should be monitored closely for any of these events.
Who should not use Mirtazapin Actavis?+
Mirtazapin Actavis is contraindicated in patients with known hypersensitivity to mirtazapine or any of its excipients, and in individuals currently taking monoamine oxidase inhibitors (MAOIs) or who have used an MAOI within the past 14 days. Caution is also advised for patients with severe hepatic impairment or uncontrolled bipolar disorder.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Mirtazapine
Route
Buccal Use , Oral Use , Sublingual Use
Manufacturer
Teva B.V
Origin
EU

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