Miraton (Loperamide Hydrochloride)

Loperamide Hydrochloride, the active ingredient in Miraton, is a peripheral μ‑opioid receptor agonist presented as an oral tablet for oral use. It treats acute and chronic diarrhea and is employed in adults and children as directed.

GNH USA supplies Miraton as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Miraton (loperamide) acts on the gastrointestinal tract to reduce excessive stool output in diarrheal disorders.

Acute diarrhea: decreases stool frequency and liquidity, providing symptomatic relief. Chronic diarrhea: helps maintain stool consistency in long‑term conditions. Irritable bowel syndrome with diarrhea: reduces urgency and improves bowel habit control.

Loperamide is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Constipation - Nausea - Abdominal cramps - Dizziness - Dry mouth - Headache

Serious or Rare Side Effects: - Severe constipation leading to ileus - Toxic megacolon - Allergic reactions such as rash or angioedema - Cardiac arrhythmias (e.g., QT prolongation) - Central nervous system depression in overdose - Hepatotoxicity in rare cases

Use Miraton only as indicated and observe safety measures. - Short‑term use only: limit therapy to the duration recommended by a healthcare professional. - Avoid in infectious diarrhea with fever or blood in stool. - Do not use if hypersensitivity to loperamide or excipients is known. - Caution in patients with hepatic impairment or severe renal disease. - Store at ambient temperature: keep in the original pack, protect from moisture.

Loperamide may interact with other medicines; review concomitant therapy.

Major Interactions (Avoid): - Concomitant use with other antidiarrheal agents may cause excessive constipation. - Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) can raise loperamide plasma levels. - CYP2C8 inhibitors (e.g., gemfibrozil) increase risk of toxicity. - Drugs that prolong QT interval (e.g., macrolide antibiotics) may heighten cardiac risk.

Moderate Interactions (Monitor Closely): - Central nervous system depressants may enhance sedation. - Other opioids can augment peripheral opioid effects. - Anticholinergic medications may worsen constipation.