Europe — EMA
Mirabella 28 (Ethinylestradiol, Levonorgestrel | Lactose)
GNH USA supplies Mirabella 28 (Ethinylestradiol and Levonorgestrel), a combined oral contraceptive for contraception and menstrual regulation.
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What is Ethinylestradiol, Levonorgestrel | Lactose?
Ethinylestradiol and Levonorgestrel, the active ingredients in Mirabella 28, are a combined oral contraceptive presented as a tablet for oral use. They work together to prevent pregnancy in women of reproductive age by inhibiting ovulation, thickening cervical mucus, and altering the endometrium.
GNH USA supplies Mirabella 28 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company ensures quality manufacturing according to EU standards and provides reliable global distribution.
What is Ethinylestradiol, Levonorgestrel | Lactose used for?
Mirabella 28, a combined oral contraceptive, is used within the hormonal contraceptive pathway to prevent unintended pregnancy.
- Contraception: prevents pregnancy in women of reproductive age. - Menstrual cycle regulation: helps establish regular menstrual bleeding patterns. - Management of dysmenorrhea: reduces the severity of painful menstrual cramps.
What are the side effects of Ethinylestradiol, Levonorgestrel | Lactose?
Common Side Effects: - Nausea: mild to moderate stomach upset. - Headache: tension‑type or migraine‑like pain. - Breast tenderness: swelling or discomfort. - Spotting or breakthrough bleeding: irregular light bleeding.
Serious or Rare Side Effects: - Venous thromboembolism: blood clots in deep veins. - Pulmonary embolism: clot migration to lungs. - Stroke or transient ischemic attack: neurological events. - Myocardial infarction: heart attack risk. - Severe allergic reaction: rash, swelling, anaphylaxis. - Liver dysfunction: jaundice or abnormal liver enzymes.
What precautions apply to Ethinylestradiol, Levonorgestrel | Lactose?
Before starting Mirabella 28, consider the following precautions: - Smoking status: avoid use if over 35 and a smoker due to increased clot risk. - Cardiovascular history: assess for hypertension, heart disease, or stroke. - History of thromboembolism: contraindicated in prior clotting events. - Liver disease: monitor liver function and avoid if severe impairment. - Pregnancy and breastfeeding: discontinue if pregnancy is confirmed; discuss risks if breastfeeding. - Store at ambient temperature: keep below 25°C, in the original packaging, protected from moisture and light.
What does Ethinylestradiol, Levonorgestrel | Lactose interact with?
Mirabella 28 may interact with several medicines.
Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): may reduce contraceptive efficacy. - Certain antiepileptics (e.g., carbamazepine, phenytoin): increase hormone metabolism. - Rifampicin and other enzyme inducers: lower plasma levels of estrogen and progestin.
Moderate Interactions (Monitor Closely): - Antifungal azoles (e.g., ketoconazole): may increase hormone concentrations. - St. John’s wort: may modestly reduce contraceptive effectiveness.



