GNH USA

Europe — EMA

Mipyrin (Paracetamol, Acetylsalicylic Acid, Caffeine)

GNH USA supplies Mipyrin (Paracetamol/Acetylsalicylic Acid/Caffeine), a analgesic for headache, migraine, fever and minor musculoskeletal pain.

Paracetamol, Acetylsalicylic Acid, Caffeine

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What is Paracetamol, Acetylsalicylic Acid, Caffeine?

Paracetamol, Acetylsalicylic Acid and Caffeine, the active ingredients in Mipyrin, are an analgesic combination presented as an oral tablet for self‑medication use. The formulation provides rapid relief of headache, migraine, fever and minor musculoskeletal pain in adult patients.

GNH USA supplies Mipyrin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards, manufactures under EU GMP guidelines and offers reliable global distribution for export to multiple markets.

What is Paracetamol, Acetylsalicylic Acid, Caffeine used for?

Mipyrin, a fixed‑dose combination analgesic, is used to treat conditions within the pain and fever pathways.

- Headache: provides rapid pain relief and reduces associated discomfort. - Migraine: alleviates migraine attacks and associated symptoms. - Fever: lowers elevated body temperature in adults. - Minor musculoskeletal pain: eases pain and inflammation in muscles and joints.

What are the side effects of Paracetamol, Acetylsalicylic Acid, Caffeine?

Common Side Effects: - Nausea: mild stomach upset may occur. - Gastric discomfort: occasional indigestion or heartburn. - Dizziness: transient light‑headedness reported. - Insomnia: caffeine may affect sleep patterns.

Serious or Rare Side Effects: - Allergic skin reactions: rash, itching or swelling. - Gastrointestinal bleeding: signs of blood in stool or vomit. - Liver enzyme elevation: abnormal liver function tests. - Severe hypersensitivity: anaphylaxis requiring immediate medical attention.

What precautions apply to Paracetamol, Acetylsalicylic Acid, Caffeine?

Before using Mipyrin, consider the following precautions: - Allergy assessment: avoid if known hypersensitivity to aspirin or related NSAIDs. - Liver function: use with caution in patients with hepatic impairment. - Ulcer risk: contraindicated in active peptic ulcer disease. - Caffeine intake: monitor total daily caffeine from all sources. - Pediatric use: avoid in children with viral infections due to Reye's syndrome risk. - Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

What does Paracetamol, Acetylsalicylic Acid, Caffeine interact with?

Major Interactions (Avoid): - Warfarin: increased risk of bleeding. - Other NSAIDs: additive gastrointestinal toxicity. - Alcohol: heightened liver injury.

Moderate Interactions (Monitor Closely): - SSRIs: possible increased bleeding tendency. - Diuretics: potential impact on renal function.

Frequently asked questions

What is Mipyrin used for?+
Mipyrin is an over‑the‑counter oral combination used to relieve headache, migraine, fever and minor musculoskeletal pain in adult patients. It combines paracetamol, acetylsalicylic acid and caffeine to provide rapid analgesic and antipyretic effects.
How does the combination of paracetamol, acetylsalicylic acid and caffeine work?+
Paracetamol reduces pain by centrally inhibiting COX enzymes and lowering prostaglandin synthesis. Acetylsalicylic acid irreversibly blocks COX‑1 and COX‑2, decreasing peripheral prostaglandin production. Caffeine antagonises adenosine receptors, which enhances the analgesic action of the other two agents and speeds up symptom relief.
What is the usual dose of Mipyrin?+
The appropriate dose of Mipyrin is determined by the prescribing healthcare professional based on the individual’s age, condition and response. Patients should follow the prescriber’s instructions and not exceed the recommended amount indicated on the product label.
Is Mipyrin safe during pregnancy or breastfeeding?+
Safety of Mipyrin in pregnancy or while breastfeeding has not been fully established. Women who are pregnant, planning pregnancy or nursing should consult their physician before using this product to weigh potential benefits against possible risks.
How do I order Mipyrin from GNH USA?+
To order Mipyrin, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Mipyrin compare with other analgesic options?+
Mipyrin combines three active ingredients, offering a broader mechanism of action than single‑component analgesics such as paracetamol alone. The addition of aspirin provides anti‑inflammatory benefits, while caffeine enhances pain relief speed. This multi‑component profile can be more effective for certain headaches or migraines compared with monotherapy, though individual response varies.
What are the storage requirements for Mipyrin?+
Mipyrin should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.
How is Mipyrin administered?+
Mipyrin is taken orally with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless directed otherwise by a healthcare professional. It is intended for use by adults and should be taken as prescribed.
What are the most serious risks associated with Mipyrin?+
Serious risks include gastrointestinal bleeding, severe allergic reactions such as anaphylaxis, and potential liver toxicity, especially when taken in excess or combined with other hepatotoxic substances. Patients should seek immediate medical attention if they notice signs of bleeding, rash, swelling, or jaundice.
Who should not use Mipyrin?+
Mipyrin should be avoided by individuals with known hypersensitivity to aspirin, paracetamol, caffeine or any component of the formulation. It is also contraindicated in patients with active peptic ulcer disease, severe liver impairment, or in children with viral infections due to the risk of Reye's syndrome.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol, Acetylsalicylic Acid, Caffeine
Route
Oral Use
Manufacturer
Cnp Pharma Gmbh
Origin
EU

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