Milurit (Allopurinol)

Allopurinol, the active ingredient in Milurit, is a xanthine oxidase inhibitor presented as an oral dosage form for oral use. By blocking the enzyme that converts purines to uric acid, it lowers serum urate levels and is employed in the management of gout attacks, chronic hyperuricemia, and to prevent tumor lysis syndrome in patients undergoing cytotoxic therapy.\n\nGNH India supplies Milurit as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing products that meet EU manufacturing standards.

Milurit (allopurinol) acts on purine metabolism and is indicated for the following conditions:\n\nGout: reduces uric acid levels to prevent acute attacks and chronic joint damage.\nHyperuricemia: maintains serum urate within target range to avoid crystal deposition.\nTumor lysis syndrome prophylaxis: lowers uric acid production in patients receiving cytotoxic therapy.

Allopurinol may cause a range of adverse reactions, which are categorized by frequency and severity.\n\nCommon Side Effects:\n- Rash: mild skin eruption.\n- Nausea: upset stomach.\n- Diarrhea: loose stools.\n- Elevated liver enzymes: mild hepatic enzyme increase.\n- Gout flare: transient increase in gout symptoms at therapy start.\n\nSerious or Rare Side Effects:\n- Stevens‑Johnson syndrome or toxic epidermal necrolysis: severe skin reactions.\n- Allopurinol hypersensitivity syndrome: multi‑organ involvement with fever, rash, eosinophilia.\n- Hepatic failure: acute liver injury.\n- Acute renal failure: sudden loss of kidney function.

When prescribing Milurit, clinicians should consider several safety measures.\n\nRenal impairment: dose may need adjustment and renal function should be monitored.\nHepatic impairment: use with caution; monitor liver enzymes regularly.\nHistory of hypersensitivity: avoid in patients with prior allergic reactions to allopurinol.\nConcomitant azathioprine or mercaptopurine: increased risk of bone‑marrow suppression.\nPregnancy and lactation: safety not established; prescribe only if benefits outweigh risks.\nStore at room temperature: keep in original container, protect from moisture and heat.

Allopurinol interacts with several medicines; some require avoidance while others need close monitoring.\n\nMajor Interactions (Avoid):\n- Azathioprine: increased bone‑marrow suppression risk.\n- Mercaptopurine: heightened toxicity.\n- Warfarin: enhanced anticoagulant effect, may raise INR.\n\nModerate Interactions (Monitor Closely):\n- NSAIDs: monitor renal function.\n- Thiazide diuretics: may reduce urate‑lowering efficacy.\n- Cyclosporine: may increase allopurinol plasma concentrations.