Milurit (Allopurinol)

Allopurinol, the active ingredient in Milurit, is a xanthine oxidase inhibitor presented as a tablet for oral use. It treats gout, hyperuricemia and helps prevent tumor lysis syndrome in appropriate patients.

GNH USA supplies Milurit as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Allopurinol is a xanthine oxidase inhibitor used in disorders of uric acid metabolism.

- Gout: reduces serum uric acid levels, decreasing the frequency of acute attacks. - Hyperuricemia: lowers elevated uric acid concentrations to target ranges. - Tumor lysis syndrome prophylaxis: prevents rapid rise in uric acid during cancer therapy.

Allopurinol may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Rash: mild skin eruptions or itching. - Gastrointestinal upset: nausea, vomiting or abdominal discomfort. - Elevated liver enzymes: transient increase in hepatic transaminases. - Diarrhea: loose stools, usually self‑limiting. - Headache: mild to moderate head pain.

Serious or Rare Side Effects: - Severe cutaneous adverse reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Aplastic anemia: bone‑marrow failure leading to pancytopenia. - Hepatotoxicity: significant liver injury with jaundice. - Acute interstitial nephritis: kidney inflammation causing renal impairment. - Hypersensitivity syndrome: fever, eosinophilia and organ involvement.

When prescribing Allopurinol, several safety considerations should be observed.

- Renal function: adjust dose in patients with impaired kidney function. - Hepatic impairment: monitor liver enzymes during therapy. - Hypersensitivity risk: discontinue immediately if rash or systemic symptoms develop. - Drug interactions: review concomitant medications that may increase toxicity. - Pregnancy and lactation: use only if clearly needed, as safety data are limited. - Store at ambient temperature: keep below 25°C in the original container, protect from moisture.

Allopurinol can interact with several medicines, affecting its efficacy or safety.

Major Interactions (Avoid): - Azathioprine or mercaptopurine: increased risk of bone‑marrow suppression. - Warfarin: enhanced anticoagulant effect, may require INR monitoring. - Amoxicillin‑clavulanate: higher incidence of severe skin reactions.

Moderate Interactions (Monitor Closely): - Thiazide diuretics: may reduce urate‑lowering effect. - ACE inhibitors or ARBs: may increase serum potassium when combined with allopurinol. - High‑dose vitamin C: may augment uric acid reduction, monitor for kidney stones.