Europe — EMA
Milk Thistle Holland And Barrett (Silybum Marianum Extract)
GNH USA supplies Milk Thistle Holland & Barrett (Silybum marianum extract), a herbal supplement for liver health support. Request a quote for global supply.
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What is Silybum Marianum Extract?
Silybum marianum extract, the active ingredient in Milk Thistle Holland & Barrett, is a herbal supplement presented as an oral formulation for oral use. It is commonly used to support liver health in adults.
GNH USA supplies Milk Thistle Holland & Barrett as a licensed, GDP‑compliant international pharmaceutical supplier serving pharmacies worldwide.
What is Silybum Marianum Extract used for?
Milk Thistle (silybum marianum extract) is primarily employed in conditions affecting liver function and oxidative stress. - Mild liver enzyme elevation: supports normalization of hepatic enzymes. - Non‑alcoholic fatty liver disease: may aid in reducing hepatic fat accumulation. - Alcohol‑related liver stress: contributes antioxidant protection to hepatocytes.
What are the side effects of Silybum Marianum Extract?
Adverse reactions to Milk Thistle are generally mild, but vigilance is advised.
Common Side Effects: - Gastrointestinal discomfort: mild abdominal upset or bloating. - Nausea: occasional feeling of queasiness. - Diarrhoea: loose stools in a minority of users. - Headache: transient mild headache. - Skin rash: mild pruritic eruption.
Serious or Rare Side Effects: - Allergic anaphylaxis: rare but potentially life‑threatening reaction. - Severe liver injury: unexpected worsening of liver function. - Jaundice: yellowing of skin or eyes indicating hepatic distress. - Significant hypotension: sudden drop in blood pressure. - Hematologic abnormalities: rare blood count changes.
What precautions apply to Silybum Marianum Extract?
When considering Milk Thistle, several safety aspects should be reviewed. - Pregnancy: safety not established; consult a healthcare professional before use. - Breastfeeding: insufficient data; use with caution. - Pre‑existing liver disease: monitor liver function tests regularly. - Concomitant medications: review for potential interactions, especially anticoagulants. - Known hypersensitivity: avoid if allergic to milk thistle or related plants. - Store at ambient temperature: keep in the original container, protect from moisture and light.
What does Silybum Marianum Extract interact with?
Milk Thistle may affect the activity of other medicines.
Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): may increase bleeding risk. - Cytochrome P450 substrates (e.g., certain statins): may alter drug metabolism.
Moderate Interactions (Monitor Closely): - Hormonal contraceptives: possible reduction in efficacy. - Diabetes medications: may affect blood glucose control. - Other hepatoprotective herbs: potential additive effects on liver enzymes.
