Mig-400 (Ibuprofen)

Ibuprofen, the active ingredient in Mig-400, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as a tablet for oral use. It treats mild to moderate pain, fever, and inflammatory conditions in adults.

GNH USA supplies Mig-400 as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen acts on inflammatory pathways to relieve pain, reduce fever, and decrease swelling.

- Mild to moderate pain: provides analgesic relief for headaches, dental pain, musculoskeletal discomfort, and other common aches. - Fever: lowers elevated body temperature by acting on the hypothalamic heat-regulating center. - Inflammatory conditions such as arthritis: diminishes joint inflammation and associated stiffness.

Adverse reactions may range from mild to severe, depending on individual susceptibility and exposure.

Common Side Effects: - Gastrointestinal upset (nausea, dyspepsia) - Headache - Dizziness - Mild rash or itching - Elevated blood pressure - Tinnitus (ringing in ears)

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulceration - Severe allergic reactions (anaphylaxis, angioedema) - Acute renal failure or significant decline in kidney function - Hepatotoxicity (liver injury) - Cardiovascular events such as myocardial infarction or stroke - Blood dyscrasias (e.g., thrombocytopenia, leukopenia).

Before using Mig-400, consider the following safety measures.

- Assess renal function: use with caution in patients with existing kidney disease. - Evaluate gastrointestinal risk: avoid in individuals with active ulcers or a history of serious GI bleeding. - Review cardiovascular status: consider increased risk of thrombotic events in patients with heart disease. - Check for hypersensitivity: do not use if allergic to ibuprofen or other NSAIDs. - Use during pregnancy and lactation only under medical advice. - Store at ambient temperature: keep in the original container, protect from moisture and heat.

Ibuprofen can affect the activity of several other medicines.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): heightened risk of bleeding. - Selective serotonin reuptake inhibitors (SSRIs): increased gastrointestinal bleeding potential. - Lithium: ibuprofen may raise lithium serum concentrations.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in renal function. - Diuretics: may exacerbate renal perfusion deficits. - Methotrexate: decreased clearance leading to toxicity. - Corticosteroids: additive risk of gastrointestinal ulceration.