Midodrine Zentiva (Midodrine Hydrochloride)

Midodrine, the active ingredient in Midodrine Zentiva, is a Alpha-1 adrenergic agonist presented as a tablet for oral use. It treats orthostatic hypotension by raising blood pressure in patients who experience a drop upon standing.

GNH USA supplies Midodrine Zentiva as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Midodrine is an alpha‑1 adrenergic agonist used to manage conditions related to low blood pressure.

- Orthostatic hypotension: raises standing systolic blood pressure and reduces dizziness or fainting. - Neurogenic orthostatic hypotension: improves vascular tone in patients with autonomic nervous system dysfunction. - Chronic hypotension: helps maintain adequate perfusion in individuals with persistently low blood pressure.

Common Side Effects: - Piloerection (goose‑bumps) - Pruritus (itching) - Urinary retention - Supine hypertension - Headache - Nausea

Serious or Rare Side Effects: - Severe hypertension, especially when lying down - Bradycardia or other arrhythmias - Myocardial ischemia or angina - Allergic reactions including rash or anaphylaxis - Chest pain - Peripheral edema

Midodrine should be used with careful clinical monitoring. - Blood pressure monitoring: check supine and standing pressures regularly. - Cardiac disease: avoid in patients with severe organic heart disease. - Renal impairment: adjust use in moderate to severe renal dysfunction. - Supine position: advise patients not to lie flat for several hours after dosing. - Concomitant antihypertensives: review and possibly adjust doses. - Store at ambient temperature: keep in the original pack, protect from moisture.

Midodrine may interact with several drug classes.

Major Interactions (Avoid): - Monoamine oxidase inhibitors (MAOIs): risk of excessive vasoconstriction. - Direct vasodilators (e.g., nitroglycerin): may counteract therapeutic effect. - Other potent antihypertensives (e.g., clonidine): can cause severe hypotension.

Moderate Interactions (Monitor Closely):\n- Diuretics: may enhance orthostatic blood pressure changes. - Beta‑blockers: may blunt compensatory heart rate response. - Tricyclic antidepressants: possible additive pressor effects.