GNH USA

Europe — EMA

Microser

GNH USA supplies Microser (Betahistine Dihydrochloride), a H1 agonist/H3 antagonist for Ménière's disease, vertigo and balance disorders.

Betahistine Dihydrochloride

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What is Betahistine Dihydrochloride?

Betahistine Dihydrochloride, the active ingredient in Microser, is a Histamine H1 receptor agonist / H3 antagonist presented as an oral tablet for oral use. It is employed to manage Ménière's disease, vertigo and other balance disorders in adult patients. GNH USA supplies Microser as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Betahistine Dihydrochloride used for?

Betahistine Dihydrochloride acts on the vestibular system and is indicated for conditions affecting inner‑ear balance.

Ménière's disease: reduces the frequency and severity of vertiginous attacks and associated tinnitus. Vertigo: alleviates episodic dizziness linked to vestibular dysfunction. Balance disorders: improves postural stability by enhancing inner‑ear microcirculation.

What are the side effects of Betahistine Dihydrochloride?

Betahistine Dihydrochloride is generally well tolerated, but adverse reactions may occur.

Common Side Effects: - Headache: mild to moderate intensity. - Nausea: occasional, often transient. - Gastric discomfort: mild indigestion or dyspepsia. - Skin rash: mild erythema or pruritus.

Serious or Rare Side Effects: - Hypotension: unexpected drop in blood pressure. - Severe allergic reaction: anaphylaxis, facial swelling, or bronchospasm. - Cardiac arrhythmia: irregular heartbeat in susceptible individuals.

What precautions apply to Betahistine Dihydrochloride?

Before initiating therapy, consider the following precautions.

Medical history review: assess for cardiovascular disease, hypertension, or asthma. Concomitant antihistamines: monitor for additive effects on blood pressure. Renal impairment: adjust monitoring as drug is excreted renally. Pregnancy and lactation: safety not established; discuss risks with a healthcare professional. Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

What does Betahistine Dihydrochloride interact with?

Betahistine may interact with other medications; awareness of the following is recommended.

Major Interactions (Avoid): - MAO inhibitors: risk of hypertensive crisis. - Strong antihistamines: may diminish therapeutic effect.

Moderate Interactions (Monitor Closely): - Antihypertensive agents: possible additive blood‑pressure lowering. - Diuretics used for Ménière's disease: monitor electrolyte balance. - CYP450 substrates: observe for altered plasma concentrations.

Frequently asked questions

What is Microser used for?+
Microser contains betahistine dihydrochloride and is used to treat vestibular disorders such as Ménière's disease, episodic vertigo, and other balance disturbances. It helps reduce the frequency and intensity of dizziness attacks by improving inner‑ear blood flow and stabilising vestibular function.
How does betahistine work?+
Betahistine acts as a histamine H1 receptor agonist and an H3 receptor antagonist. This dual activity increases histamine release in the inner ear, causing vasodilation of the stria vascularis, enhancing microcirculation, and reducing vestibular hyperexcitability, which collectively lessen vertigo symptoms.
What is the usual dose of Microser?+
The appropriate dose of Microser is determined by the prescribing clinician based on the patient’s condition, age, and response to therapy. Healthcare professionals tailor the regimen to achieve optimal symptom control while monitoring for tolerability.
Is Microser safe during pregnancy or breastfeeding?+
Safety data for betahistine during pregnancy and lactation are limited. It is classified as a category where risk cannot be ruled out, so clinicians should evaluate the potential benefits against possible risks before prescribing to pregnant or nursing individuals.
How do I order Microser from GNH USA?+
To request Microser, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Microser compare with other anti‑vertigo drugs?+
Compared with diuretic‑based therapies such as acetazolamide or loop diuretics, betahistine primarily improves inner‑ear microcirculation rather than reducing fluid volume. It generally has a more favourable side‑effect profile, but efficacy may vary, and some clinicians combine it with diuretics for refractory cases.
How should Microser be stored and handled?+
Microser tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original blister pack, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.
How is Microser administered?+
Microser is taken orally, usually with or without food, as directed by a healthcare professional. The tablets are swallowed whole with a glass of water and should not be crushed or chewed unless specifically advised by the prescriber.
What are the most serious risks associated with Microser?+
Serious adverse reactions, although rare, include significant hypotension, severe allergic responses such as anaphylaxis, and cardiac arrhythmias. Patients should seek immediate medical attention if they experience sudden drops in blood pressure, difficulty breathing, swelling of the face or throat, or irregular heartbeats.
Who should not use Microser?+
Microser is contraindicated in individuals with known hypersensitivity to betahistine or any excipients in the tablet. Caution is advised for patients with uncontrolled hypertension, severe cardiovascular disease, or those taking monoamine oxidase inhibitors, as the combination may increase the risk of adverse events.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Betahistine Dihydrochloride
Route
Oral Use
Manufacturer
Grünenthal Italia S.R.L.
Origin
EU

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