Mezym

Pancreas powder from porcine, the active ingredient in Mezym, is a digestive enzyme presented as a powder for oral use. It treats exocrine pancreatic insufficiency and related conditions in patients with cystic fibrosis, chronic pancreatitis, or other causes of pancreatic enzyme deficiency.

GNH USA supplies Mezym as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Mezym provides exogenous pancreatic enzymes to support digestion in disorders characterized by exocrine pancreatic insufficiency.

- Exocrine pancreatic insufficiency: improves digestion and nutrient absorption. - Cystic fibrosis: aids breakdown of fats, proteins, and carbohydrates, reducing malabsorption. - Chronic pancreatitis: supplements deficient pancreatic enzymes to alleviate steatorrhea and weight loss.

Mezym may cause adverse reactions, most of which are mild and reversible.

Common Side Effects: - Abdominal discomfort: mild pain or cramping after ingestion. - Flatulence: increased gas production. - Nausea: feeling of queasiness. - Oily or fatty stools: steatorrhea due to unabsorbed fat.

Serious or Rare Side Effects: - Allergic reaction: rash, itching, swelling, or anaphylaxis. - Severe abdominal pain: may indicate pancreatitis exacerbation. - Respiratory distress: difficulty breathing or wheezing. - Serum sickness–like reaction: fever, joint pain, and rash. - Persistent diarrhea: leading to dehydration and electrolyte imbalance.

Before using Mezym, consider the following precautions.

- Dose adjustment: may be required in patients with renal or hepatic impairment. - Allergy assessment: avoid if known hypersensitivity to porcine proteins. - Monitoring: watch for signs of malabsorption or fat‑soluble vitamin deficiency. - Drug interactions: consider concomitant acid‑suppressing therapy which may reduce enzyme activation. - Store at ambient temperature: keep in the original container, protect from moisture and heat.

Mezym can interact with other medications that affect gastric acidity or bind proteins.

Major Interactions (Avoid): - Proton pump inhibitors: may reduce enzyme activation in the acidic environment. - Antacids containing aluminum or magnesium: can bind enzymes and lower their activity.

Moderate Interactions (Monitor Closely): - Orlistat: may interfere with fat digestion and enzyme efficacy. - Cholestyramine: can bind enzymes and reduce their activity. - High‑dose vitamin supplements: may affect enzyme function or absorption.