Mezavant Xl

Mesalazine, the active ingredient in Mezavant XL, is an aminosalicylate presented as an extended‑release tablet for oral use. It is employed to reduce inflammation in the colon of patients with ulcerative colitis, helping to maintain remission and control symptoms.

GNH USA supplies Mezavant XL as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network adheres to EU quality standards and ensures timely delivery to healthcare providers across multiple regions. We maintain rigorous temperature and humidity controls for all oral solid dosage forms.

Mesalazine is used to treat inflammatory bowel disease, specifically ulcerative colitis, by delivering topical anti‑inflammatory action in the colon.

- Ulcerative colitis (induction): reduces active inflammation to achieve remission. - Ulcerative colitis (maintenance): helps sustain remission and prevent flare‑ups. - Proctitis (ulcerative colitis limited to rectum): provides localized anti‑inflammatory effect.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Abdominal pain: cramping or discomfort. - Headache: occasional tension‑type headache. - Diarrhea: loose stools may occur.

Serious or Rare Side Effects: - Myocarditis: inflammation of heart muscle requiring immediate care. - Severe allergic reaction: rash, swelling, or anaphylaxis. - Blood dyscrasias: neutropenia or agranulocytosis. - Hepatotoxicity: significant liver enzyme elevation. - Pancreatitis: abdominal pain with elevated enzymes. - Toxic colitis: severe colonic inflammation.

Before initiating therapy, consider the following precautions: - Assess renal function: adjust use in severe renal impairment. - Monitor hepatic enzymes: discontinue if significant elevation occurs. - Avoid in known hypersensitivity: stop if rash or anaphylaxis develops. - Use caution in pregnancy: limited data, weigh benefits against risks. - Avoid concomitant NSAIDs: may increase gastrointestinal toxicity. - Store at ambient temperature: keep below 25 °C, protect from moisture and light.

Mesalazine may interact with several medicines. Review the following:

Major Interactions (Avoid): - Azathioprine: increased risk of bone marrow suppression. - Methotrexate: additive hepatotoxicity. - Warfarin: may enhance anticoagulant effect.

Moderate Interactions (Monitor Closely): - Oral corticosteroids: may increase infection risk. - Antibiotics (e.g., fluoroquinolones): may alter gut flora affecting drug release. - Lithium: monitor serum levels for potential changes.