GNH USA

Europe — EMA

Mezavant

GNH USA supplies Mezavant (Mesalazine), a aminosalicylate for maintenance of remission in ulcerative colitis. Request a quote for global supply today.

Mesalazine

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What is Mesalazine?

Mesalazine, the active ingredient in Mezavant, is an aminosalicylate presented as a tablet for oral use. It is used to maintain remission in ulcerative colitis patients.\n\nGNH India supplies Mezavant as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Mesalazine used for?

Mezavant is an aminosalicylate that acts on inflammatory bowel disease, particularly ulcerative colitis.\n\nUlcerative colitis (induction of remission): reduces colonic inflammation to achieve symptom control.\nUlcerative colitis (maintenance of remission): helps sustain disease remission and prevent relapse.\nUlcerative colitis (mild to moderate disease): provides anti‑inflammatory effect throughout the colon.

What are the side effects of Mesalazine?

Adverse reactions may occur with any medication and should be monitored.\n\nCommon Side Effects:\n- Nausea\n- Headache\n- Abdominal pain\n- Diarrhea\n\nSerious or Rare Side Effects:\n- Severe allergic reaction (e.g., anaphylaxis)\n- Blood dyscrasias such as neutropenia or agranulocytosis\n- Interstitial nephritis or other kidney inflammation

What precautions apply to Mesalazine?

Safety considerations are important when prescribing Mezavant.\n\nMonitor renal function: assess serum creatinine before and during therapy.\nAssess hepatic function: check liver enzymes periodically.\nAvoid use in patients with known hypersensitivity to mesalazine.\nUse with caution in patients with sulfonamide allergy.\nPregnancy and breastfeeding: discuss risks with healthcare provider.\nStore at ambient temperature: keep below 25 °C, protect from moisture and light.

What does Mesalazine interact with?

Drug interaction potential should be reviewed before initiating therapy.\n\nMajor Interactions (Avoid):\n- Anticoagulants (e.g., warfarin): may increase bleeding risk.\n- Non‑steroidal anti‑inflammatory drugs (NSAIDs): may exacerbate renal toxicity.\n- Methotrexate: may increase mesalazine levels and toxicity.\n\nModerate Interactions (Monitor Closely):\n- Oral corticosteroids: may increase risk of infection.\n- Diuretics: may affect renal clearance of mesalazine.

Frequently asked questions

What is Mezavant used for?+
Mezavant contains mesalazine and is prescribed to help maintain remission in patients with ulcerative colitis. By reducing inflammation in the colon, it aims to keep symptoms under control and lower the chance of disease flare‑ups.
How does mesalazine work?+
Mesalazine works locally in the intestinal lining where it blocks cyclooxygenase and lipoxygenase enzymes. This inhibition reduces the production of prostaglandins and leukotrienes, key mediators of inflammation, thereby decreasing mucosal irritation and promoting healing.
What is the usual dose of Mezavant?+
The dose of Mezavant is individualized by the prescribing clinician based on disease severity, patient weight, and response to therapy. Healthcare providers determine the appropriate strength and frequency, and patients should follow the prescribed regimen exactly.
Is Mezavant safe during pregnancy or breastfeeding?+
Safety data for mesalazine in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and benefits with their healthcare professional.
How do I order Mezavant from GNH USA?+
To request Mezavant, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Mezavant compare with other IBD treatments?+
Mezavant belongs to the aminosalicylate class, which is generally used for mild‑to‑moderate ulcerative colitis. Compared with biologic agents, it has a more favorable safety profile but may be less effective in severe disease. It is often used before escalating to immunomodulators or biologics.
What are the storage and handling requirements for Mezavant?+
Mezavant tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture and direct light, and ensure the packaging remains tightly closed until use.
How is Mezavant administered?+
Mezavant is taken orally as a tablet. Patients should swallow the tablet whole with a glass of water, usually with or without food, as directed by their prescriber. The tablet should not be crushed or chewed unless specifically advised.
What are the most serious risks associated with Mezavant?+
The most serious adverse events include severe allergic reactions such as anaphylaxis, kidney inflammation (interstitial nephritis), and blood disorders like neutropenia or agranulocytosis. Patients should seek immediate medical attention if they experience symptoms such as rash, fever, unexplained bruising, or changes in urine output.
Who should not use Mezavant?+
Mezavant is contraindicated in individuals with a known hypersensitivity to mesalazine or any component of the tablet. It should also be avoided in patients with severe renal or hepatic impairment unless specifically directed by a specialist, and in those with a history of severe sulfonamide allergy.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Mesalazine
Route
Oral Use
Manufacturer
Takeda Pharmaceuticals International Ag Ireland Branch
Origin
EU

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