Mexolan

Meloxicam, the active ingredient in Mexolan, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an injectable formulation for intramuscular use. It treats pain and inflammation associated with osteoarthritis, rheumatoid arthritis and other musculoskeletal conditions in adults.

GNH USA supplies Mexolan as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Meloxicam is used to manage inflammatory and painful conditions affecting the musculoskeletal system.

- Pain relief: Provides symptomatic reduction of mild to moderate pain linked to inflammatory disorders. - Osteoarthritis: Improves joint function and decreases pain in degenerative joint disease. - Rheumatoid arthritis: Reduces joint swelling and stiffness in autoimmune arthritis. - Musculoskeletal inflammation: Alleviates inflammation in soft‑tissue injuries and other inflammatory musculoskeletal conditions.

Adverse reactions may vary in frequency and severity.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain. - Headache: mild to moderate intensity. - Dizziness or vertigo. - Injection site reactions: redness, swelling, or pain at the intramuscular site. - Peripheral edema: mild swelling of the lower limbs. - Elevated liver enzymes: mild, transient increases.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Cardiovascular events: myocardial infarction or stroke. - Renal impairment or failure. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Hepatic dysfunction: hepatitis or liver failure. - Anaphylactic or severe hypersensitivity reactions.

Before initiating therapy, clinicians should consider several safety factors.

- Renal function assessment: adjust use in patients with impaired kidney function. - Gastrointestinal risk: evaluate history of ulcers or bleeding before prescribing. - Cardiovascular evaluation: use caution in patients with established heart disease. - Hepatic monitoring: check liver enzymes periodically during treatment. - Hypersensitivity screening: avoid in individuals with known meloxicam or NSAID allergy. - Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Meloxicam may interact with other medicines, requiring careful management.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal and renal toxicity. - Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding potential.

Moderate Interactions (Monitor Closely): - Diuretics: possible reduction in renal clearance of meloxicam. - ACE inhibitors or ARBs: may diminish antihypertensive effect and affect kidney function. - Methotrexate: potential for increased methotrexate toxicity.