Metronidazole Remedica

Metronidazole, the active ingredient in Metronidazole Remedica, is a nitroimidazole antibiotic presented as an oral tablet for oral use. It treats anaerobic bacterial and protozoal infections in adults and adolescents.

GNH USA supplies Metronidazole Remedica as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Metronidazole is indicated for a range of anaerobic bacterial and protozoal infections. - Bacterial vaginosis: eradicates the pathogenic bacterial flora and restores normal vaginal microbiota. - Trichomoniasis: eliminates Trichomonas vaginalis, relieving symptoms and preventing recurrence. - Amoebic dysentery (Entamoeba histolytica): clears intestinal amoebae and resolves dysenteric symptoms. - Anaerobic bacterial infections (intra‑abdominal, pelvic, skin and soft‑tissue): provides bactericidal activity against susceptible anaerobes. - Clostridioides difficile infection (adjunct therapy): reduces toxin‑producing bacterial load when used with standard therapy.

Metronidazole may cause a range of adverse reactions.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Metallic taste: transient metallic sensation in the mouth. - Diarrhea: loose stools, sometimes watery. - Headache: mild to moderate headache. - Abdominal pain: cramping or discomfort in the abdomen. - Skin rash: mild erythema or itching.

Serious or Rare Side Effects: - Seizures: convulsions, especially with high plasma levels. - Peripheral neuropathy: tingling or numbness in extremities. - Severe allergic reactions: anaphylaxis, angioedema, or Stevens‑Johnson syndrome. - Hepatic dysfunction: jaundice or elevated liver enzymes. - Pancytopenia: reduction in blood cell counts. - Disulfiram‑like reaction: flushing, tachycardia, and hypotension when alcohol is consumed.

Before prescribing Metronidazole, clinicians should consider several safety factors. - Renal function assessment: adjust use in severe renal impairment. - Hepatic monitoring: evaluate liver enzymes during prolonged therapy. - Alcohol avoidance: advise patients of a disulfiram‑like reaction. - Pregnancy risk evaluation: weigh potential benefits against unknown fetal risk. - Hypersensitivity check: discontinue if signs of severe allergy appear. - Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Metronidazole can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Alcohol: may cause a disulfiram‑like reaction with flushing, tachycardia and nausea. - Warfarin: potentiates anticoagulant effect, increasing bleeding risk. - Lithium: may raise lithium serum concentrations, leading to toxicity.

Moderate Interactions (Monitor Closely): - Phenytoin: reduces metronidazole levels, potentially decreasing efficacy. - Cimetidine: can increase metronidazole plasma concentrations. - Carbamazepine: may lower metronidazole exposure, requiring clinical monitoring.