GNH USA

Europe — EMA

Metronidazole Fresenius

GNH USA supplies Metronidazole Fresenius (Metronidazole), a nitroimidazole antibiotic for anaerobic bacterial infections, intra‑abdominal infections

Metronidazole

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What is Metronidazole?

Metronidazole, the active ingredient in Metronidazole Fresenius, is a nitroimidazole presented as an injectable solution for intravenous use. It is employed to treat anaerobic bacterial infections and related conditions such as intra‑abdominal infections, pelvic inflammatory disease, bacterial vaginosis, trichomoniasis, and amebic dysentery in adult patients.

GNH USA supplies Metronidazole Fresenius as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

What is Metronidazole used for?

Metronidazole is indicated for infections caused by anaerobic bacteria and certain protozoa.

Anaerobic bacterial infections: effective against mixed anaerobic flora in intra‑abdominal and soft‑tissue infections. Intra‑abdominal infections: reduces bacterial load in peritonitis and postoperative infections. Pelvic inflammatory disease: targets anaerobic organisms contributing to PID. Bacterial vaginosis: eradicates Gardnerella and other anaerobes causing vaginal discharge. Trichomoniasis: eliminates Trichomonas vaginalis in genital infections. Amebic dysentery: treats Entamoeba histolytica intestinal infection.

What are the side effects of Metronidazole?

Metronidazole may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea - Metallic taste - Headache - Dizziness - Abdominal pain - Diarrhea

Serious or Rare Side Effects: - Seizures - Peripheral neuropathy - Severe allergic reactions (anaphylaxis) - Stevens‑Johnson syndrome - Neutropenia - Hepatic dysfunction

What precautions apply to Metronidazole?

When using Metronidazole Fresenius, several precautions should be observed to minimize risk.

Renal function: adjust use in severe renal impairment. Hepatic function: monitor liver enzymes during prolonged therapy. Pregnancy: Category B – prescribe only when benefit outweighs potential risk. Alcohol: avoid concurrent consumption due to disulfiram‑like reaction. CNS depressants: may enhance central nervous system effects. Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

What does Metronidazole interact with?

Metronidazole can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid): - Alcohol: may cause severe disulfiram‑like reaction. - Warfarin: can enhance anticoagulant effect, increasing bleeding risk. - Lithium: may increase lithium toxicity.

Moderate Interactions (Monitor Closely): - Phenytoin: may reduce metronidazole plasma levels. - Cimetidine: can increase metronidazole concentrations. - Rifampin: may decrease metronidazole effectiveness.

Frequently asked questions

What is Metronidazole Fresenius used for?+
Metronidazole Fresenius is an intravenous nitroimidazole antibiotic used to treat infections caused by anaerobic bacteria and certain protozoa, including intra‑abdominal infections, pelvic inflammatory disease, bacterial vaginosis, trichomoniasis, and amebic dysentery in adult patients.
How does Metronidazole work?+
Metronidazole is taken up by anaerobic microorganisms and reduced to reactive nitro radical anions. These radicals damage DNA by causing strand breaks and loss of helical stability, which blocks nucleic acid synthesis and leads to cell death, providing selective activity against anaerobes and some protozoa.
What is the usual dose of Metronidazole Fresenius?+
The dosing regimen for Metronidazole Fresenius is determined by the prescribing clinician based on the infection type, severity, patient weight, and renal or hepatic function. Typical intravenous courses range from 500 mg to 1 g every 8 hours, but exact dosing must follow the prescriber’s order.
Is Metronidazole safe during pregnancy or breastfeeding?+
Metronidazole is classified as Pregnancy Category B, indicating that animal studies have not shown risk to the fetus and there are no adequate human studies. It may be used during pregnancy only if the potential benefit justifies any potential risk. Limited data suggest it is compatible with breastfeeding, but clinical judgment is required.
How do I order Metronidazole Fresenius from GNH USA?+
To order Metronidazole Fresenius, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials. The sales team then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.
How does Metronidazole compare with its main alternative drug?+
The primary alternative to metronidazole for anaerobic infections is clindamycin. Both agents cover similar anaerobic bacteria, but metronidazole has superior activity against certain protozoa (e.g., Trichomonas, Entamoeba) and a lower risk of Clostridioides difficile infection. Clindamycin may be preferred when metronidazole intolerance occurs, but it carries a higher incidence of gastrointestinal side effects.
What are the storage requirements for Metronidazole Fresenius?+
Metronidazole Fresenius should be stored refrigerated at 2 °C to 8 °C. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the solution. If a temporary temperature excursion occurs, discard the product if visual changes are observed.
How is Metronidazole Fresenius administered?+
Metronidazole Fresenius is given by intravenous infusion. The solution is typically diluted in compatible IV fluids (e.g., 5% dextrose or normal saline) and infused over 30–60 minutes, depending on the prescribed dose and clinical setting. Administration should follow aseptic technique and institutional infusion protocols.
What are the most serious risks to watch for with Metronidazole?+
Serious adverse events associated with metronidazole include seizures, peripheral neuropathy (which may be irreversible), severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, neutropenia, and hepatic dysfunction. Patients should be monitored for neurological symptoms, skin reactions, and liver function abnormalities during therapy.
Who should not use Metronidazole Fresenius?+
Metronidazole Fresenius should be avoided in individuals with a known hypersensitivity to metronidazole or other nitroimidazoles, in patients with severe hepatic impairment, and in those who are currently consuming alcohol due to the risk of a disulfiram‑like reaction. Caution is also advised for patients with significant renal dysfunction.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metronidazole
Route
Intravenous Use
Manufacturer
Fresenius Kabi Deutschland Gmbh
Origin
EU

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