Metronidazole Fresenius

Metronidazole, the active ingredient in Metronidazole Fresenius, is a nitroimidazole antibiotic presented as an intravenous solution for IV use. It treats anaerobic bacterial infections, bacterial vaginosis, trichomoniasis, intra‑abdominal infections and pelvic inflammatory disease in appropriate patients.

GNH USA supplies Metronidazole Fresenius as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Metronidazole is used to manage infections caused by anaerobic microorganisms and related conditions.

- Anaerobic bacterial infections: eliminates anaerobic pathogens and resolves infection. - Bacterial vaginosis: restores normal vaginal flora by targeting anaerobic bacteria. - Trichomoniasis: eradicates Trichomonas vaginalis in affected individuals. - Intra‑abdominal infections: controls polymicrobial infections within the abdominal cavity. - Pelvic inflammatory disease: treats mixed aerobic‑anaerobic pelvic infections.

Metronidazole may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Metallic taste: transient metallic sensation in the mouth. - Headache: occasional mild headache. - Dizziness: occasional light‑headedness. - Abdominal discomfort: mild cramping or pain. - Diarrhoea: loose stools during therapy.

Serious or Rare Side Effects: - Seizures: rare neurologic events. - Stevens‑Johnson syndrome: severe skin reaction. - Peripheral neuropathy: tingling or numbness in extremities. - Anaphylaxis: life‑threatening allergic response. - Severe neutropenia: marked reduction in white blood cells. - Hepatic dysfunction: elevated liver enzymes or liver injury.

Metronidazole requires careful consideration of patient factors and handling.

- Renal impairment: assess kidney function and adjust therapy if needed. - Hepatic dysfunction: monitor liver enzymes during treatment. - Alcohol consumption: avoid alcohol to prevent disulfiram‑like reaction. - Pregnancy: use only when benefits outweigh potential risks. - Warfarin co‑administration: monitor INR closely for enhanced anticoagulation. - Store at below 25°C: keep in original container, protect from light and moisture.

Metronidazole can interact with several medicines, influencing safety and efficacy.

Major Interactions (Avoid): - Alcohol: may cause severe disulfiram‑like reaction. - Lithium: increased lithium toxicity risk. - Warfarin: potentiates anticoagulant effect, raising bleeding risk.

Moderate Interactions (Monitor Closely): - Cimetidine: may raise metronidazole plasma levels. - Phenobarbital: can reduce metronidazole concentrations. - Phenytoin: may lower metronidazole exposure.