Metronidazole Fresenius

Metronidazole, the active ingredient in Metronidazole Fresenius, is a nitroimidazole presented as an injection for intravenous use. It treats anaerobic bacterial infections and certain protozoal diseases in adults and children as prescribed.

GNH USA supplies Metronidazole Fresenius as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals worldwide.

Metronidazole is used to treat infections caused by anaerobic bacteria and susceptible protozoa.

- Anaerobic bacterial infections: effective against mixed anaerobic infections, reducing bacterial load and clinical symptoms. - Bacterial vaginosis: restores normal vaginal flora by eliminating over‑growth of anaerobic organisms. - Trichomoniasis: eradicates Trichomonas vaginalis, relieving symptoms and preventing recurrence. - Amebic liver abscess: eliminates Entamoeba histolytica in hepatic tissue, aiding resolution of the abscess. - Clostridioides difficile infection: suppresses toxin‑producing C. difficile, helping to control colitis.

Metronidazole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Metallic taste: transient alteration of taste perception. - Headache: occasional mild to moderate headache. - Diarrhea: loose stools that may be self‑limiting.

Serious or Rare Side Effects: - Seizures: rare neurologic events, especially with high plasma levels. - Peripheral neuropathy: tingling or numbness in extremities with prolonged use. - Severe allergic reactions: anaphylaxis or angioedema requiring immediate medical attention.

Metronidazole requires careful consideration of patient‑specific factors before use. - Pregnancy: safety not established; use only if benefits outweigh potential risks. - Renal impairment: dose may need adjustment; monitor renal function regularly. - Hepatic impairment: caution advised; monitor liver enzymes during therapy. - Alcohol consumption: avoid; concurrent intake can cause a disulfiram‑like reaction. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Metronidazole can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Alcohol: may produce severe disulfiram‑like reactions. - Warfarin: can enhance anticoagulant effect, increasing bleeding risk. - Lithium: may raise lithium concentrations, leading to toxicity.

Moderate Interactions (Monitor Closely): - Oral contraceptives: may reduce hormonal efficacy, consider backup contraception. - Cimetidine: can increase metronidazole plasma levels, monitor for toxicity.