GNH USA

Europe — EMA

Metronidazole B.Braun

GNH USA supplies Metronidazole B.Braun (Metronidazole), a nitroimidazole antibiotic for anaerobic bacterial infections, bacterial vaginosis, and C.

Metronidazole

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What is Metronidazole?

Metronidazole, the active ingredient in Metronidazole B.Braun, is a nitroimidazole antibiotic (ATC code J01XD01) presented as an injectable solution for intravenous administration. It is used to treat anaerobic bacterial infections and selected protozoal diseases in both adult and pediatric patients under medical supervision, and is classified under the therapeutic class of antibiotic, antiprotozoal agents.

GNH USA supplies Metronidazole B.Braun as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide for sterile compounding and inpatient use, with full regulatory support and reliable logistics.

What is Metronidazole used for?

Metronidazole is a nitroimidazole antibiotic indicated for infections caused by anaerobic bacteria and certain protozoa.

Anaerobic bacterial infections: effective against mixed intra‑abdominal, skin, soft‑tissue and dental infections. Bacterial vaginosis: restores normal vaginal flora by eliminating pathogenic anaerobes. Trichomoniasis: eradicates Trichomonas vaginalis in genital infections. Amebic dysentery: treats intestinal amebiasis caused by Entamoeba histolytica. Clostridioides difficile infection: used for severe or recurrent C. difficile colitis.

What are the side effects of Metronidazole?

Metronidazole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea - Headache - Metallic taste - Diarrhea - Abdominal pain - Dizziness

Serious or Rare Side Effects: - Peripheral neuropathy - Seizures - Stevens‑Johnson syndrome - Anaphylactic reaction - Hepatotoxicity - Severe neutropenia

What precautions apply to Metronidazole?

Before using Metronidazole B.Braun, consider the following precautions to ensure safe administration.

Renal or hepatic impairment: adjust dosing and monitor function. Alcohol consumption: avoid, as disulfiram‑like reaction may occur. Neurological disorders: monitor for peripheral neuropathy. Pregnancy and lactation: use only if benefits outweigh risks. Drug interactions: review concomitant medications for major interactions. Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

What does Metronidazole interact with?

Metronidazole can interact with several medicines; interactions are categorized by clinical significance.

Major Interactions (Avoid): - Alcohol: may cause severe disulfiram‑like reaction. - Warfarin: increased anticoagulant effect, monitor INR. - Lithium: risk of toxicity, monitor levels. - Cimetidine: may increase metronidazole plasma concentrations. - Phenobarbital: may reduce efficacy of metronidazole.

Moderate Interactions (Monitor Closely): - Benzodiazepines: enhanced sedation. - Anticonvulsants (phenytoin, carbamazepine): may decrease metronidazole levels. - Oral contraceptives: possible reduced efficacy. - Theophylline: increased plasma levels. - Rifampin: may lower metronidazole concentrations.

Frequently asked questions

What conditions is Metronidazole B.Braun used to treat?+
Metronidazole B.Braun is indicated for a range of anaerobic bacterial infections such as intra‑abdominal, skin and soft‑tissue infections, as well as protozoal diseases including bacterial vaginosis, trichomoniasis, amebic dysentery, and severe Clostridioides difficile colitis. It is administered intravenously under medical supervision.
How does Metronidazole work?+
Metronidazole is taken up by susceptible anaerobic organisms, where its nitro group is enzymatically reduced to reactive nitro radicals. These radicals damage DNA and inhibit nucleic acid synthesis, leading to loss of cellular integrity and death of the bacterial or protozoal cell.
What determines the dose of Metronidazole B.Braun?+
The dosage of Metronidazole B.Braun is individualized by the prescribing clinician based on the type and severity of infection, patient weight, renal and hepatic function, and other clinical factors. No fixed regimen is provided here; the prescriber sets the appropriate dose.
Is Metronidazole safe in pregnancy or breastfeeding?+
The pregnancy safety category for Metronidazole is not definitively established. It is generally avoided during the first trimester unless the benefit outweighs the potential risk. Use during lactation should be considered carefully, as the drug is excreted in breast milk; a healthcare professional should evaluate the situation.
How do I order Metronidazole B.Braun from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team will then provide pricing, availability, shipping details (including cold‑chain logistics if needed) and any required import documentation.
How does Metronidazole compare with other antibiotics for anaerobic infections?+
Metronidazole is often preferred for strict anaerobic bacteria because of its targeted mechanism and oral‑to‑IV flexibility. Alternatives such as clindamycin or beta‑lactam/beta‑lactamase inhibitor combinations may be used, but they can have broader spectra and different side‑effect profiles. Choice depends on pathogen susceptibility, infection site, and patient tolerance.
What are the storage and handling requirements for Metronidazole B.Braun?+
Metronidazole B.Braun should be stored refrigerated at 2‑8 °C. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking. If a temporary temperature excursion occurs, consult the product’s stability data before use.
How is Metronidazole B.Braun administered?+
The product is supplied as an injectable solution for intravenous infusion. It is reconstituted with the appropriate diluent, inspected for clarity, and administered over the prescribed period, typically via a peripheral or central line under aseptic conditions. Administration details are provided by the prescribing clinician.
What are the most serious risks to watch for with Metronidazole B.Braun?+
Serious adverse events include peripheral neuropathy, which may be irreversible if not recognized early, seizures, severe hypersensitivity reactions such as Stevens‑Johnson syndrome, hepatotoxicity, and profound neutropenia. Patients should be monitored for neurological symptoms, skin reactions, and liver function abnormalities during therapy.
Who should not use Metronidazole B.Braun?+
Metronidazole B.Braun is contraindicated in individuals with known hypersensitivity to metronidazole or other nitroimidazole derivatives. Caution is advised for patients with severe hepatic impairment, those receiving disulfiram, and patients with a history of seizures or severe neurological disorders. The drug should be avoided in such cases unless the clinical benefit justifies the risk.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metronidazole
Route
Intravenous Use
Manufacturer
B.Braun Melsungen Ag
Origin
EU

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