Metronidazole B. Braun

Metronidazole, the active ingredient in Metronidazole B. Braun, is a nitroimidazole antibiotic presented as an intravenous solution for intravenous use. It treats anaerobic bacterial infections and certain protozoal infections in hospitalized patients.

GNH USA supplies Metronidazole B. Braun as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Metronidazole is employed to manage infections caused by anaerobic bacteria and susceptible protozoa. - Anaerobic bacterial infections: eradicates susceptible anaerobes, reducing infection severity. - Bacterial vaginosis: restores normal vaginal flora by eliminating pathogenic anaerobes. - Trichomoniasis: eliminates Trichomonas vaginalis, relieving symptoms. - Intra‑abdominal infections: controls mixed aerobic‑anaerobic infections following surgery or perforation. - Pelvic inflammatory disease: treats anaerobic components of PID, improving clinical outcomes. - Clostridioides difficile‑associated diarrhea (adjunct): reduces toxin‑producing bacterial load when used with standard therapy.

Metronidazole may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Metallic taste: transient metallic sensation in the mouth. - Headache: occasional dull or throbbing pain. - Diarrhea: loose stools during therapy. - Abdominal pain: cramping or discomfort. - Dizziness: light‑headed feeling.

Serious or Rare Side Effects: - Seizures: rare neurologic events, especially with high doses. - Severe allergic reactions: anaphylaxis, rash, or angioedema. - Stevens‑Johnson syndrome: severe skin and mucous membrane involvement. - Peripheral neuropathy: tingling or numbness in extremities. - Neutropenia: marked reduction in white blood cells. - Hepatotoxicity: elevated liver enzymes or liver injury.

Metronidazole requires careful monitoring in specific clinical situations. - Renal function assessment: adjust use in severe renal impairment. - Hepatic monitoring: observe liver enzymes during prolonged therapy. - Pregnancy caution: avoid in the first trimester unless benefits outweigh risks. - CNS disorders: use cautiously in patients with seizure disorders. - Allergic reaction: discontinue immediately if severe hypersensitivity occurs. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Metronidazole can interact with several medications, altering efficacy or safety.

Major Interactions (Avoid): - Alcohol: may cause a disulfiram‑like reaction with flushing and tachycardia. - Warfarin: potentiates anticoagulant effect, increasing bleeding risk. - Lithium: may raise lithium levels, leading to toxicity.

Moderate Interactions (Monitor Closely): - Phenytoin: may reduce metronidazole plasma concentrations. - Cimetidine: can increase metronidazole levels, enhancing side effects. - Carbamazepine: may lower metronidazole efficacy, requiring clinical observation.